SM_3 is a sulfated glycolipid, in which the neutral sugar chain is modified by sulfate residue. The amount of sulfated glycolipids in normal liver cell is very small, however, highly expression of SM_3 is found in human heptacellular carcinoma (HCC) cells and tissues. Therefore, it is suggested that SM_3 may be the important cancer associated carbohydrate antigen of HCC. In this paper, one spacer- armed analogue of a disaccharide SM_3 was synthesized for the first time via multi-step synthetic method. The target compound is suitable for conjugation to a carrier by the presence of a 2-amino ethyl spacer, and therefore is useful for application in immunological study later.

Key words: OLIGOSACCHARIDE, ANTICARCINOGEN, ANTIGENS