Acta Chimica Sinica ›› 2003, Vol. 61 ›› Issue (9): 1382-1387. Previous Articles     Next Articles

Original Articles

钇离子及其阳离子卟啉配合物与金黄色葡萄球菌的相互作用

侯安新;刘义;黄伟国;薛智;屈松生   

  1. 武汉大学化学与分子科学学院;香港浸会大学化学系
  • 发布日期:2003-09-15

Interaction of Y~(3+) and Its Cationic Monoporphyrinate Complex with Staphylococcus aureus

Hou Anxin;Liu Yi;Wong Wai-kwok;Xue Zhi;Qu Songsheng   

  1. Department of Chemistry, Wuhan University;Department of Chemistry, Hong Kong Baptist University
  • Published:2003-09-15

The biothermochemical characteristics of the actions of Y , TMP and their cationic monoporphyrinate complex |[Y(TMP)(H2O)3]Cl, TMP= 5,10, 15,20-tetrakis(4'-methoxyphenyl)porphyrin| on growth metabolism of Staphylococcus aureus were studied by means of a LKB-2277 Bioactivity Monitor at 37.00 ℃. The growth rate constants k_1, k_2 inhibiting ratio I( %), the total heat effect (Q_(total)) and half inhibition of concentration IC50 (mg· L~(-1)), respectively were obtained. Experimental results show that Y~(3+) and [Y(TMP) (H_2O)_3]C1 have the duplex biological effection: they stimulate the growth of the Staphylococcus aureus at lower concentration but inhibit the growth at high concentration. Inhibitory effection of Y~(3+) , TMP and [Y(TMP) (H_2O)_3]Cl is [Y(TMP)(H_2O)_3]C1> TMP>Y~(3+).

Key words: YTTRIUM COMPOUNDS, PORPHYRIN, STAPHYLOCOCCUS ARUEUS, THERMODYNAMICS, DEPRESSING

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