Aminoantipyrine Imprinted Column Prepared by in-situ Polymerization and Investigation of Binding Character in Aqueous Medium

Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (12): 1176-1179. Previous Articles Next Articles

氨基安替比林分子原位烙印柱的制备及其水中结合性质的研究

范子琳¹, 杨更亮^1,2, 张国庆¹, 刘海燕¹, 陈义²

1. 河北大学药学院, 保定, 071002;
2. 中国科学院化学研究所分子科学中心, 北京, 100080

投稿日期:2003-10-31 修回日期:2004-01-08 发布日期:2014-02-17
通讯作者: 杨更亮,E-mail:ygl@mail.hbu.edu.cn;Tel:0312-5079788 E-mail:ygl@mail.hbu.edu.cn
基金资助:
国家自然科学基金(No.20375010)、河北省自然科学基金(No.202096)、科学技术部基金(Nos.2002CB713803,KJCX-S5W-H06)、中国科学院"百人计划"和教育部优秀教师资助项目.

Aminoantipyrine Imprinted Column Prepared by in-situ Polymerization and Investigation of Binding Character in Aqueous Medium

FAN Zi-Lin¹, YANG Geng-Liang^1,2, ZHANG Guo-Qing¹, LIU Hai-Yan¹, CHEN Yi²

1. College of Pharmacy, Hebei University, Baoding 071002;
2. Molecular Science Center, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080

Received:2003-10-31 Revised:2004-01-08 Published:2014-02-17

Abstract

Aminoantipyrine imprinted column was prepared by in situ polymerization in a 50 mm×4.6 mm I D. stainless steel column. Methacrylic acid (MAA), ethylene glycol dimethacrylate (EDMA), 2,2'-azobisisobutyronitrile (AIBN) were used as the monomer, crosslinker and initiator, respectively. Dodecanol and toluene were used as porogen. Both organic and aqueous mobile phases were applied for the evaluation of the chromatographic character of the column, and the mechanism of molecular recognition was discussed. It was found that the imprinted column showed high selectivity towards aminoantipyrine in aqueous medium. Ionic and hydrophobic interactions were presumed as the reasons for the molecule recognition in aqueous medium. Under the optimum condition, the retention factor of aminoantipyrine could achieve 94 41. Rectangular pulse frontal analysis method was adopted to determine the single component absorption isotherms. In contrast with the retention factors gained from molecular imprinting polymers, the accordant results were obtained.

Key words: molecular imprinting, recognition in aqueous medium, in-situ polymerization, aminoantipyrine

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FAN Zi-Lin, YANG Geng-Liang, ZHANG Guo-Qing, LIU Hai-Yan, CHEN Yi. Aminoantipyrine Imprinted Column Prepared by in-situ Polymerization and Investigation of Binding Character in Aqueous Medium[J]. Acta Chimica Sinica, 2004, 62(12): 1176-1179.

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氨基安替比林分子原位烙印柱的制备及其水中结合性质的研究

Aminoantipyrine Imprinted Column Prepared by in-situ Polymerization and Investigation of Binding Character in Aqueous Medium

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