s Direct enantiomeric resolution of five novel chiral tetrahedrane-type clusters has firstly been achieved on cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase, using hexane as the mobile phase with various alcohols as modifiers.The influence of the mobile phase composition on the enantioselectivity was discussed, and the effect of structural variation of the solutes on their enantioseparation was also investigated and compared.It was found that both the metal in the tetrahedral core and the ligand coordinated to the atom in tetrahedral core had significant effects on their chromatographic behaviors.

Key words: cellulose tris(3,5-dimethylphenylcarbamate), chiral transition metal tetrahedral cluster, enantioseparation