Syntheses, Characterization and DNA-binding Studies of Novel Asymmetric Tridentate Polypyridine Ligands and Their Heteroleptic Ruthenium(Ⅱ) Complexes

Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (7): 692-696. Previous Articles Next Articles

新型不对称三齿多吡啶配体及其混配钌(Ⅱ)配合物的合成、表征及与DNA相互作用研究

蒋才武

广西中医学院药学院, 南宁, 530001

投稿日期:2003-08-12 修回日期:2003-10-19 发布日期:2014-02-18
通讯作者: 蒋才武,E-mail:cwjiang@gxtcmu.edu.cn;Fax:0771-3137377 E-mail:cwjiang@gxtcmu.edu.cn
基金资助:
广西中医学院高学历科研启动基金(No.G00217)和国家自然科学基金(No.30070188)资助项目.

Syntheses, Characterization and DNA-binding Studies of Novel Asymmetric Tridentate Polypyridine Ligands and Their Heteroleptic Ruthenium(Ⅱ) Complexes

JIANG Cai-Wu

School of Pharmacy, Guangxi Traditional Chinese Medical University, Nanning 530001

Received:2003-08-12 Revised:2003-10-19 Published:2014-02-18

Abstract

Two novel asymmetric tridentate polypyridine ligands with as-triazole, 3-(1,10-phenanthrolin-2-yl)-1,2,4-triazole (PHT) and 3-(1,10-phenanthrolin-2-yl)-5-methyl-1,2,4-triazole (PHMT) have been designed, synthesized, and characterized by microanalyses, FAB-MS, NMR, FT-IR, and UV-vis. Their heteroleptic complexes [Ru(tpy)(PHT)](ClO₄)₂·H₂O (Ru1) and [Ru(tpy)(PHMT)](ClO₄)₂ܨH₂O (Ru2) were synthesized and investigated with microanalyses, ES-MS, NMR and cyclic voltammetry. DNA binding mechanisms of the complexes were studied by electronic absorption spectra, competitive binding, and viscosity measurements. The results indicated that the modes of these two complexes interacting with DNA were electrostatic interaction, and the DNA-binding of Ru2 was stronger than that of Ru1.

Key words: ruthenium(Ⅱ)complex, tridentate polypyridine ligand, DNA binding

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JIANG Cai-Wu. Syntheses, Characterization and DNA-binding Studies of Novel Asymmetric Tridentate Polypyridine Ligands and Their Heteroleptic Ruthenium(Ⅱ) Complexes[J]. Acta Chimica Sinica, 2004, 62(7): 692-696.

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新型不对称三齿多吡啶配体及其混配钌(Ⅱ)配合物的合成、表征及与DNA相互作用研究

Syntheses, Characterization and DNA-binding Studies of Novel Asymmetric Tridentate Polypyridine Ligands and Their Heteroleptic Ruthenium(Ⅱ) Complexes

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