Synthetic Studies of the HIV-Inhibitive Marine Natural Products --Synthesis of the C1～C7 Fragment of Didemnaketal A

Acta Chimica Sinica ›› 2004, Vol. 62 ›› Issue (8): 839-841. Previous Articles Next Articles

抗HIV活性海洋天然产物Didemnaketals的合成研究——C1～C7片段的合成

李学强^1,2, 王洪¹, 涂永强¹, 王少华¹

1. 兰州大学化学化工学院, 功能有机分子化学国家重点实验室, 兰州, 730000;
2. 宁夏大学化学化工学院, 银川, 750021

投稿日期:2003-10-20 修回日期:2003-12-26 发布日期:2014-02-18
通讯作者: 涂永强,E-mail:tuyq@lzu.edu.cn E-mail:tuyq@lzu.edu.cn
基金资助:
国家自然科学基金(Nos.30271488,20021001,203900501)资助项目.

Synthetic Studies of the HIV-Inhibitive Marine Natural Products --Synthesis of the C1～C7 Fragment of Didemnaketal A

LI Xue-Qiang^1,2, WANG Hong¹, TU Yong-Qiang¹, WANG Shao-Hua¹

1. Department of Chemistry and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
2. Department of Chemistry, Ningxia University, Yinchuan 750021

Received:2003-10-20 Revised:2003-12-26 Published:2014-02-18

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CLC Number:

O629

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LI Xue-Qiang, WANG Hong, TU Yong-Qiang, WANG Shao-Hua. Synthetic Studies of the HIV-Inhibitive Marine Natural Products --Synthesis of the C1～C7 Fragment of Didemnaketal A[J]. Acta Chimica Sinica, 2004, 62(8): 839-841.

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[13] (3R,4S,6R)-3,4-di[(tert-butyl dimethylsilyl)oxy]-7-hydroxy-6-methylheptan-2-one (5) [α]_D²⁵-10.0 (c 1.5, CHCl₃); ¹H NMR (CDCl₃, 200 MHz) δ: 4.09 (d, J=3.6 Hz, 1H, 3-H), 3.94～3.92 (m, 1H, 4-H), 3.42 (dd, J=5.1, 5.8 Hz, 2H, OCH₂), 2.20 (s, 3H, 1-H), 1.73～0.80 (m, 4H, OH, 5-H, and 6-H), 0.94 [s, 9H, C(CH₃)₃], 0.92 (d, J=4.0 Hz, 3H, CH₃), 0.90 [s, 9H, C(CH₃)3], 0.09 (s, 3H, SiCH₃), 0.07 (s, 3H, SiCH₃), 0.06 (s, 3H, SiCH₃), 0.04 (s, 3H, SiCH₃); ¹³C NMR (CDCl₃, 100 MHz) δ: 210.7, 80.6, 73.6, 68.1, 37.9, 32.0, 28.3, 25.8 (6C), 18.2, 18.0, 17.4, -4.4, -4.7, -4.8, -5.1; FAB-MS m/z (%): 405 (M⁺+1, 5), 387 (80), 347 (24), 245 (14), 215 (100), 115 (100); HRMS (ESI) calcd for C₂0H₄₄Si₂O₄Na (M+Na)⁺ 427.2670, found 427.2673.

抗HIV活性海洋天然产物Didemnaketals的合成研究——C1～C7片段的合成

Synthetic Studies of the HIV-Inhibitive Marine Natural Products --Synthesis of the C1～C7 Fragment of Didemnaketal A

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