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Acta Chimica Sinica ›› 2005, Vol. 63 ›› Issue (8): 783-786. Previous Articles    

Reports

双核钌(II)多吡啶配合物与酵母RNA的相互作用研究

蒋尚达1，王科志*1，刘芙蓉1，张永安1，高丽华2   

  1. (1北京师范大学化学系 北京 100875)
    (2北京工商大学化学与环境工程学院 北京 100037)
  • 投稿日期:2004-08-04 修回日期:2004-12-28 发布日期:2010-12-10
  • 通讯作者: 王科志

Interaction of a Dinuclear Polypyridyl Ruthenium(II) Complex with Yeast-RNA

JIANG Shang-Da1, WANG Ke-Zhi*1, LIU Fu-Rong1, ZHANG Yong-An1, GAO Li-Hua2   

  1. (1 Department of Chemistry, Beijing Normal University, Beijing 100875)
    (2 School of Chemical and Environment Engineering, Beijing Technology and Business University, Beijing 100037)
  • Received:2004-08-04 Revised:2004-12-28 Published:2010-12-10
  • Contact: WANG Ke-Zhi

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The binding of a dinuclear Ru(II) complex of [(bpy)2Ru(ebipcH2)Ru(bpy)2](ClO4)4, where bpy＝2,2'-bipyridine and ebipcH2＝N-ethyl-4,7-bis(imidazolo[4,5-f]-(1,10-phenanthrolin)-2-yl)carbazole, to yeast-RNA has been investigated by UV-visible and emission spectroscopy titrations, steady-state emission quenching and reverse salt titration experiments. The results suggest that the binding of this complex to the RNA be intercalative with a binding constant of 9.1×105 L/mol at 50 mmol/L NaCl, which is much stronger than to the DNA at physiological saline concentration (≈150 mmol/L NaCl).

Key words: ruthenium(II) complex, yeast-RNA, intercalation