ESI-mass Spectral Fragmentation Pathways of DNA Recognizing Polyamides

Acta Chimica Sinica ›› 2005, Vol. 63 ›› Issue (9): 834-840. Previous Articles Next Articles

Original Articles

聚酰胺类DNA识别分子质谱的碎裂机理

李钦玲^{1 2}，周江¹，汤菲力¹，袁谷*¹

(¹北京大学化学学院化学生物学系生物有机与分子工程教育部重点实验室北京 100871)
(²青海民族学院化学系西宁 810007)

投稿日期:2004-08-03 修回日期:2005-01-11 发布日期:2010-12-10
通讯作者: 袁谷

ESI-mass Spectral Fragmentation Pathways of DNA Recognizing Polyamides

LI Qin-Ling², ZHOU Jiang¹, TANG Fei-Li¹, YUAN Gu*¹

(¹Department of Chemical Biology, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871)
(²Department of Chemistry, Qinghai University for Nationalities, Xi'ning 810007)

Received:2004-08-03 Revised:2005-01-11 Published:2010-12-10
Contact: YUAN Gu

Abstract

Mass spectral fragmentation mechanisms of eight polyamides containing N-methylpyrrole and N-methylimidazole were investigated by electrospray ionization tandem mass spectrometry. The ESI-MSⁿ data show that the principal fragmentation pathways of the polyamides are the cleavage of C—CO, CO—NH and NH—C bonds of the amide groups, or together with rearrangement of hydrogen atom. The differences of the ESI mass spectra suggest the structural information of polyamides, and the two isomers were distinguished by ESI-MS.

Key words: polyamide, ESI mass spectrometry, fragmentation pathway

Cite this article

LI Qin-Ling², ZHOU Jiang, TANG Fei-Li, YUAN Gu*^{1. ESI-mass Spectral Fragmentation Pathways of DNA Recognizing Polyamides[J]. Acta Chimica Sinica, 2005, 63(9): 834-840.}

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Huang Lei, Huang Tong, Bai Yongping, Zhou Yongfeng. Hierarchical Self-assembly of Polyamide Helical Fibers [J]. Acta Chim. Sinica, 2016, 74(12): 990-994.
[2]	. Semi-aromatic Copolyamide: Synthesis and Thermal Stability [J]. Acta Chimica Sinica, 2009, 67(9): 983-988.
[3]	. Construction and ESI-MS Analysis of Homocyclic Peptide Libraries Assisted by Inorganic Phosphorus Reagents [J]. Acta Chimica Sinica, 2009, 67(18): 2109-2115.
[4]	QI Wei; JIA Chen-Xi; HE Zhi-Min*; QIAO Bin. Multistep Tandem Mass Spectrometry for Sequencing Cyclic Peptides Axinastatin 1 and Deducing Fragmentation Pathways [J]. Acta Chimica Sinica, 2007, 65(3): 233-238.
[5]	PENG Shu-Ying; HUANG Xin; CHEN Jun-Hua; YANG Yi-Ming; SHEN Jian-Hua*. Study on the Mass Spectrometric Behavior of Depsidones by Electrospray Tandem Mass Spectrometry [J]. Acta Chimica Sinica, 2007, 65(24): 2883-2890.
[6]	ZHOU Jiang; YUAN Gu*. Effect of pH and Cations on the Formation and Structure of Human Telomeric G-Quadruplex DNA [J]. Acta Chimica Sinica, 2007, 65(16): 1728-1732.
[7]	LI Hui-Hui; HAN De-Wei; YUAN Gu*. Investigation of Interaction of HIV-1 DNA and Polyamides, Imide Derivatives by Electrospray Ionization Mass Spectrometry [J]. Acta Chimica Sinica, 2007, 65(16): 1543-1547.
[8]	GU Wei-Xing, WU Pei-Yi, YANG Yu-Liang. Two-dimensional (2D) Correlation Analysis of Variable-temperature Fourier-transform Infrared Spectra of Polyamide 6 [J]. Acta Chimica Sinica, 2004, 62(20): 2123-2126.
[9]	Wang Kangcheng;Gao Chao;Huang Wei;Xu Yimin;Yan Deyue. Synthesis of Water-soluble Hyperbranched Polymer with Alternating Amido, Tertiary Amino and Ester Units from Benzene-1,2,4-tricarboxylic Acid-1,2-anhydride and N-(2-Hydroxyethyl)piperazine [J]. Acta Chimica Sinica, 2003, 61(5): 795-799.
[10]	Sun Wenxiu;Hu Xianbo;Xu Yizhuang;Qu Liangwei;Yang Zhanlan;Wang Dujin;Liu Xuexin;Guo Fanxiu;Weng Shifu;Wu Jinguang;Xu Duanfu. Study on the interaction between polyamide and lanthanide ions [J]. Acta Chimica Sinica, 2000, 58(12): 1602-1607.
[11]	LU YAFEI;YANG XIAOZHEN;ZHU SHANNONG;LI XIANGKUI. Infrared spectra of nylon 1010 [J]. Acta Chimica Sinica, 1983, 41(6): 525-533.

聚酰胺类DNA识别分子质谱的碎裂机理

ESI-mass Spectral Fragmentation Pathways of DNA Recognizing Polyamides

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 11

Recommended Articles

Metrics

Comments