Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (14): 1513-1516. Previous Articles    

Reports

从猪去氧胆酸甲酯表观合成角鲨多胺

沈季铭,周向东,周维善*   

  1. (中国科学院上海有机化学研究所 上海 200032)
  • 投稿日期:2005-11-24 修回日期:2006-03-24 发布日期:2006-07-28
  • 通讯作者: 周维善

Formal Synthesis of Squalamine from Methylhyodeoxycholanate

SHEN Ji-Ming, ZHOU Xiang-Dong, ZHOU Wei-Shan*   

  1. (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)
  • Received:2005-11-24 Revised:2006-03-24 Published:2006-07-28
  • Contact: ZHOU Wei-Shan

A marine steroid squalamine with antibacteria and antitumor activity was formally synthesized in 15 steps with 5.6% overall yield from methylhyodeoxycholanate.

Key words: squalamine, methylhyodeoxycholanate, formal synthesis