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Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (17): 1799-1804. Previous Articles     Next Articles

Original Articles

TiO2纳米颗粒对钌(II)三联吡啶配合物光损伤小牛胸腺DNA能力的影响

丁慧颖1,2; 宋林青1; 陈景荣1; 王雪松*,1; 张宝文*,1   

  1. (1中国科学院理化技术研究所 北京 100101)
    (2中国科学院研究生院 北京 100039)
  • 投稿日期:2006-02-27 修回日期:2006-04-13 发布日期:2006-09-14
  • 通讯作者: 张宝文

Effects of TiO2 Nanoparticles on the Photodamage of CT-DNA by Ru(II) Bis(terpyridine) Complexes

DING Hui-Ying1,2; SONG Lin-Qing1; CHEN Jing-Rong1; WANG Xue-Song*,1; ZHANG Bao-Wen*,1   

  1. (1 Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101)
    (2 Graduate School of the Chinese Academy of Sciences, Beijing 100039)
  • Received:2006-02-27 Revised:2006-04-13 Published:2006-09-14
  • Contact: ZHANG Bao-Wen

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Due to their short excited state lifetimes, Ru(II) bis(terpyridine) complexes can hardly used as DNA photocleavers. In this paper three Ru(II) bis(terpyridine) complexes [Ru(ttp)(tpy)]2＋ (1), [Ru(ttp- COOH)(tpy)]2＋ (2) and [Ru(ttp-COOH)(tpy-pyr)]2＋ (3) were designed and synthesized (tpy＝2,2':6',2"- terpyridine, ttp＝4'-(p-tolyl)-2,2':6',2"-terpyridine, ttp-COOH＝4'-(p-carboxyl-phenyl)-2,2':6',2"-terpyridine, tpy-pry＝4'-(1-pyrenyl)-2,2':6',2"-terpyridine). It was found that TiO2 nanoparticles improved the photodamage ability of 3 on calf thymus DNA in both aerated and deaerated conditions. The oxidized form of 3, [Ru(III)(ttp-COOH)(tpy-pyr)]3＋, generated by photoinduced electron transfer between TiO2 nanoparticle and 3, was invoked to account for the enhanced DNA photodamage.

Key words: Ru(II) complex, terpyridine ligand, TiO2 nanoparticle, photoinduced electron transfer, calf thymus DNA, photodamage