Pauson-Khand Approach towards Enantiopure C2-Symmetric Polycyclic Compound from D-Mannitol

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Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (2): 169-174. Previous Articles Next Articles

Original Articles

利用甘露醇骨架和Pauson-Khand反应合成光学纯的C2轴对称性多环酮类结构

姚祝军

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投稿日期:2005-08-04 修回日期:2005-09-22 发布日期:2006-01-28
通讯作者: 姚祝军

Pauson-Khand Approach towards Enantiopure C2-Symmetric Polycyclic Compound from D-Mannitol

Received:2005-08-04 Revised:2005-09-22 Published:2006-01-28

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Abstract

The enantiopure C2-symmetric polycyclic compound 1 with multiple functional groups was synthesized efficiently using a two-directional regio- and stereoselective intramolecular Pauson-Khand reaction upon the precursor derived from D-mannitol. The full target structure was established and confirmed by the corresponding NMR and X-ray crystallography studies.

Key words: Pauson-Khand reaction, regioselectivity, stereoslectivity, C2-symmetry, polycyclic compound

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利用甘露醇骨架和Pauson-Khand反应合成光学纯的C2轴对称性多环酮类结构

Pauson-Khand Approach towards Enantiopure C2-Symmetric Polycyclic Compound from D-Mannitol

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