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Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (7): 589-592.     Next Articles

Original Articles

海藻硫酸多糖抑制草酸钙结石形成的化学模拟

邓穗平1，欧阳健明*,1,2，吴秀梅1，王凤新1，岑颖洲2   

  1. (1暨南大学生物矿化与结石病防治研究所 广州 510632)
    (2暨南大学化学系 广州 510632)
  • 投稿日期:2005-07-01 修回日期:2005-12-02 发布日期:2006-04-15
  • 通讯作者: 欧阳健明

Chemical Simulation on Inhibition of Calcium Oxalate Stones by Eucheuma striatum Polysaccharide

DENG Sui-Ping1, OUYANG Jian-Ming*,1,2, WU Xiu-Mei1, WANG Feng-Xin1, CEN Ying-Zhou2   

  1. (1 Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632)
    (2 Department of Chemistry, Jinan University, Guangzhou 510632)
  • Received:2005-07-01 Revised:2005-12-02 Published:2006-04-15
  • Contact: OUYANG Jian-Ming

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The influence of sulfated polysaccharide (ESPS) isolated from marine algae Eucheuma striatum on crystallization of calcium oxalate crystals was investigated in urine of lithogenic patient in vitro. SPS could inhibit the growth and aggregation of calcium oxalate monohydrate (COM) and induce the formation of calcium oxalate dihydrate crystals due to the strong electrostatic interactions between the Ca2＋-rich (101) crystal faces of COM and the polyanionic polysaccharide. This result indicated that SPS may be a potential inhibitor to calcium oxalate urinary stones.

Key words: calcium oxalate, algal polysaccharide, urinary stone