The spontaneous formation of vesicle induced by charged solid nanoparticle was reported. When mixing 5.0 g/L Mg₃Al hydrotalcite-like compound (HTlc) sol and 0.02 mol/L surfactant solution of zwitterionic surfactant, dodecyl betaine (C₁₂BE), and anionic surfactant, sodium bis(2-ethylhexyl) sulfosuccinate (AOT), with molar ratio of C₁₂BE to AOT equal to 3∶2, it was found that Mg₃Al HTlc nanoparticles with structural positive charges may induce spontaneous formation of vesicles in the volume ratio range of the HTlc sol to the surfactant solution from 1∶9 to 4∶6, and a stable HTlc-vesicle composite was formed. The obtained HTlc-vesicle composite was characterized by negative-staining TEM and dynamic light scattering. Some HTlc nanoparticles were possi-bly enveloped in vesicles.

Key words: vesicle, hydrotalcite-like compound, zwitterionic surfactant, anionic surfactant