Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (16): 1543-1547. Previous Articles     Next Articles

Communications

电喷雾质谱法研究聚酰胺、酰亚胺衍生物与HIV-1基因DNA的相互作用

李卉卉, 韩德伟, 袁谷*   

  1. (北京大学化学学院化学生物学系 北京分子科学国家实验室 生物有机与分子工程教育部重点实验室 北京 100871)
  • 投稿日期:2007-03-30 修回日期:2007-05-20 发布日期:2007-08-28
  • 通讯作者: 袁谷

Investigation of Interaction of HIV-1 DNA and Polyamides, Imide Derivatives by Electrospray Ionization Mass Spectrometry

LI Hui-Hui; HAN De-Wei; YUAN Gu*   

  1. (Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic and Molecular Engineering of Education Ministry, College of Chemistry, Department of Chemical Biology, Peking University, Beijing 100871)
  • Received:2007-03-30 Revised:2007-05-20 Published:2007-08-28
  • Contact: YUAN Gu

Electrospray ionization mass spectrometry was utilized to investigate the non-covalent interaction of HIV-1 gene and six DNA-recognizing molecules. It revealed that imide derivative 4, a potent binder of HIV-1 DNA, had the higher binding affinity with the duplex DNA among six DNA-recognizing molecules.

Key words: HIV-1 gene, ESI-MS, DNA-recognizing molecule, polyamide, imide derivative