Fourteen cucurbitane compounds, including five new ones named delavanosides A～E (1～5), and nine known ones identified as carnosiflogenin A (6), scandenoside R8 (7), carnosifloside I (8), carnosifloside II (9), carnosifloside III (10), hemslecin A (11), hemslecin B (12), 2-O-β-D-glycoside of hemslecin A (13) and scandenoside R1 (14), were isolated from the tubers of Hemsleya delavayi. On the basis of spectral analysis and chemical methods, the new compounds were elucidated as 3β,27-dihydroxycucurbita-5,24-dien- 11-on-27-O-β-D-glucopyranosyl(1®2)-β-D-glucopyranoside (1), 3β,20,27-trihydroxycucurbita-5,24-dien- 11-on-27-O-β-D-glucopyranosyl(1®2)-b-D-glucopyranoside (2), 3β,20,27-trihydroxycucurbita-5,24-dien- 11-on-3-O-β-D-glucopyranosyl-27-O-β-D-glucopyranosyl(1®2)-β-D-glucopyranoside (3), 3β,26-dihydroxy- cucurbita-5,24-dien-11-on-3-O-β-D-glucopyranoside (4) and 3β,26-dihydroxycucurbita-5,24-dien-11-on-3- O-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl(1®6)-β-D-glucopyranosyl(1®2)-β-D-glucopyranoside (5). Compound 6 was also firstly isolated as a natural product.

Key words: Hemsleya delavayi, Cucurbitaceae, delavanoside A～E, cucurbitane compound