Effect of pH and Cations on the Formation and Structure of Human Telomeric G-Quadruplex DNA

Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (16): 1728-1732. Previous Articles Next Articles

Reports

溶液pH和阳离子对端粒G-四链体DNA形成和结构的影响

周江, 袁谷*

(北京大学化学与分子工程学院化学生物学系北京分子科学国家实验室生物有机与分子工程教育部重点实验室北京 100871)

投稿日期:2007-03-29 修回日期:2007-05-24 发布日期:2007-08-28
通讯作者: 袁谷

Effect of pH and Cations on the Formation and Structure of Human Telomeric G-Quadruplex DNA

ZHOU Jiang; YUAN Gu*

(Beijing National Laboratory for Molecular Sciences and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871)

Received:2007-03-29 Revised:2007-05-24 Published:2007-08-28
Contact: YUAN Gu

Abstract

Electrospray ionization mass spectrometry and circular dichroism were used to investigate the factors which affect the motif of the human telomeric quadruplex, such as pH and cations. ESI-MS and CD spectra indicated that pH could induce both the conformational transition and the dissociation of the quadruplex. Moreover, K^＋and NH₄^＋ cations play an important role in the formation of the quadruplex.

Key words: telomere, G-quadruplex DNA, ESI mass spectrometry, circular dichroism

Cite this article

ZHOU Jiang; YUAN Gu*. Effect of pH and Cations on the Formation and Structure of Human Telomeric G-Quadruplex DNA[J]. Acta Chimica Sinica, 2007, 65(16): 1728-1732.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Xiaomao Tian, Yuequn Lin, Han Zhu, Chao Huang, Bixue Zhu. Enantiomers Identification of Penicillamine by Chiral Mono-Schiff Base Macrocycles [J]. Acta Chimica Sinica, 2023, 81(1): 20-28.
[2]	Long Saran, Wan Yan, Xia Andong. Spectral Properties of Water-Soluble Conjugated Polymer PFP/DNA/Porphyrin Complex [J]. Acta Chim. Sinica, 2015, 73(7): 723-728.
[3]	Liu Ying, Chen Xiaoman, Zhang Langqi, Sun Dongdong, Zhou Yanhui, Chen Lanmei, Liu Jie. Stabilization of Telomere DNA, and Mechanism of Apoptosis of Tumor Cells Induced by Ruthenium Complexes [J]. Acta Chimica Sinica, 2014, 72(4): 473-480.
[4]	LIU Lu-Sha, FAN Jun, HU Chun-Mei, SUN Yang, HU Xiao-Yun, ZHAO Ying-Yong, WEI Song, LIANG Xu-Hua. Studies on the Interaction between TubeimosideII and Human Serum Albumin by Spectroscopic Methods [J]. Acta Chimica Sinica, 2011, 69(21): 2589-2596.
[5]	XU Fei, ZHANG Lin-Qun, HE Li-Wei, GU Wei, FANG Fang, WU Qi-Nan, ZHAO Bo. Molecular Mechanism on the Interaction between Alisols and Human Serum Albumin [J]. Acta Chimica Sinica, 2011, 69(19): 2228-2234.
[6]	MENG Chen-Peng, WANG Shun, ZHANG Ke-Jun, JIN Hui-Le, CHEN Xi-An, HU Mao-Lin, XIONG Jing. Electrochemical Study on the Interactions between Enantiomer of 2-(5-Fluorouracil-1-acetyl)amido-1,5-dimethyl Glutarate and Double-stranded/G-quadruplex DNA [J]. Acta Chimica Sinica, 2011, 69(10): 1173-1178.
[7]	SONG Yu-Min, LIU Zhe, WANG Kun-Jie, LUAN Ni-Na. Interaction of the Ternary Complexes with Anticoagulant Property of Iron, Copper with Human Serum Albumin [J]. Acta Chimica Sinica, 2010, 68(21): 2191-2198.
[8]	LV Jian-Quan , WANG Xue-Mei, 吕Gui-Ying , SUN Ting-Quan, TANG Jin-Yan, XU Ming-Bo. Effect of pH, Quercetin and Zinc Ion on the Structure of β-Casein by Circular Dichroism Method [J]. Acta Chimica Sinica, 2010, 68(14): 1449-1453.
[9]	TONG Shang-Lun, HU Zhou, LIU Wei-Ping. Study on the Interaction between Paraquat and Calf Thymus DNA by Spectral Methods [J]. Acta Chimica Sinica, 2010, 68(14): 1404-1410.
[10]	LIN Li-Rong, HU Wang-Xia, MA Jie, ZHANG Hui, HUANG Rong-Ban, ZHENG Lan-Sun. Spontaneous Chiral Symmetry Breaking of (Thio)semicarbazide Compounds [J]. Acta Chimica Sinica, 2010, 68(07): 703-706.
[11]	. Thermodynamic Study on Interaction of Oxymatrine with Bovine Serum Albumin [J]. Acta Chimica Sinica, 2009, 67(18): 2155-2158.
[12]	MANG Chao-Yong^,1 ZHAO Xia LIU Cai-Ping² WU Ke-Chen^{,2. Chiral Recognitions of Organic Small Molecules by Cobalt(III)-Porphyrin [J]. Acta Chimica Sinica, 2008, 66(2): 195-199.}
[13]	LI Lin-Wei*; WANG Dong-Dong; SUN De-Zhi; LIU Min; QU Xiu-Kui. Thermodynamic Study on Interaction between Anti-tumor Drug 5-Fluorouracil and Human Serum Albumin [J]. Acta Chimica Sinica, 2007, 65(24): 2853-2857.
[14]	LIU Min^1,2; SUN De-Zhi²; LIN Rui-Sen*^,1; QU Xiu-Kui²; WANG Xu²; LI Ling². Interaction between Human Serum Albumin and Bis-quaternary Ammonium Surfactants [J]. Acta Chimica Sinica, 2007, 65(2): 123-128.
[15]	CHEN Ke-Hai^1,2; ZHENG Xue-Fang*^,1; GUO Ming²; CAO Hong-Yu; TANG Qian; YANG Yan-Jie. Investigation on the Interaction of Vincristine with Human Serum Al-bumin [J]. Acta Chimica Sinica, 2007, 65(17): 1887-1891.

溶液pH和阳离子对端粒G-四链体DNA形成和结构的影响

Effect of pH and Cations on the Formation and Structure of Human Telomeric G-Quadruplex DNA

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments