Total Synthesis of (±)-Rosmarinic Acid

Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (08): 945-948. Previous Articles Next Articles

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(±)-迷迭香酸(Rosmarinic acid)的全合成

袁虎¹，单磊²，孙青龑*^,2，韩伟*^,1

(¹华东理工大学药学院上海 200237)
(²第二军医大学药学院上海 200433)

投稿日期:2010-11-16 修回日期:2010-12-27 发布日期:2010-12-27
通讯作者: 袁虎 E-mail:ahuoo86@163.com
基金资助:
863计划;长江学者创新团队计划

Total Synthesis of (±)-Rosmarinic Acid

Yuan Hu¹ Shan Lei² Sun Qingyan*^,2 Han Wei*^,1

(¹East China University of Science and Technology, School of Pharmacy, Shanghai 200237)
(²The Second Military Medical University, College of Pharmacy, Shanghai 200433)

Received:2010-11-16 Revised:2010-12-27 Published:2010-12-27
Contact: Hu YUAN E-mail:ahuoo86@163.com

(±)-Rosmarinic acid was synthesized from vertraldethyde by the reaction of Erlenmeyer, hydrolytic loop-open, reduction, carboxyl protection, esterification, Kunz-Waldmann procedure and demethylation. The methods of demethylation of methylated Rosmarinic acid were studied. An efficient synthetic route of (±)-rosmarinic acid with cheap materials was obtained.

Key words: vertraldethyde, demethylation, total synthesis, (±)-rosmarinic acid

CLC Number:

0621.3

Cite this article

YUAN Hu, DAN Lei, SUN Qing-Yan, HAN Wei. Total Synthesis of (±)-Rosmarinic Acid[J]. Acta Chimica Sinica, 2011, 69(08): 945-948.

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(±)-迷迭香酸(Rosmarinic acid)的全合成

Total Synthesis of (±)-Rosmarinic Acid

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