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Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (13): 1589-1591. Previous Articles    

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去乙酰基-7-氨基头孢烷酸二苯甲酯的合成

王阁, 曹小辉, 于亮, 陈立功*   

  1. (天津大学化工学院 天津 300072)
  • 投稿日期:2010-09-30 修回日期:2011-01-13 发布日期:2011-03-17
  • 通讯作者: 陈立功 E-mail:lgchen@tju.edu.cn
  • 基金资助:

    国家自然科学基金项目

Synthesis of Benzhydryl 7-Amino-3-(hydroxymethyl)-8-oxo-5- thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

WANG Ge, CAO Xiao-Hui, YU Liang, CHEN Li-Gong   

  1. (School of Chemical Engineering, Tianjin University, Tianjin 300072)
  • Received:2010-09-30 Revised:2011-01-13 Published:2011-03-17
  • Contact: Ligong Chen E-mail:lgchen@tju.edu.cn

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Cefcapene Pivoxil is important one of the fourth generational cephalosporin antibiotics. The synthesis of Cefcapene Pivoxil from D-7ACA has been intensively studied. Normally, it is involved to protect the carboxyl group of D-7ACA. Thus, it is very important to study the protection of carboxyl group of D-7ACA. Benzhydryl 7-amino-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylate was obtained from D-7ACA with diphenyldiazo-methane as protection reagent, enhanced by ultrasonic wave, in 70% yield.

Key words: D-7ACA, diphenyldiazomethane, carboxyl protection, cefcapene pivoxil, ultrasonic wave