Molecular Mechanism on the Interaction between Alisols and Human Serum Albumin

Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (19): 2228-2234. Previous Articles Next Articles

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泽泻醇类化合物与血清白蛋白相互作用的分子机理研究

徐飞¹，张林群^2,3，何立巍¹，谷巍¹，房方¹，吴启南*^,1，赵波*^,4

(¹南京中医药大学南京210046)
(²东南大学化学化工学院南京211189)
(³南京师范大学分析测试中心南京210097)
(⁴南京师范大学化学与环境科学学院南京210097）)

投稿日期:2011-01-14 修回日期:2011-05-17 发布日期:2011-06-09
通讯作者: 吴启南 E-mail:qnlxw@yahoo.com.cn
基金资助:
江苏省普通高校研究生科研创新计划;江苏省中医药局行业专项资助课题

Molecular Mechanism on the Interaction between Alisols and Human Serum Albumin

Xu Fei¹ Zhang Linqun^2,3 He Liwei¹ Gu Wei¹ Fang Fang¹ Wu Qinan*^,1 Zhao Bo*^,4

(¹Nanjing University of Chinese Medicine, Nanjing 210046)
(²School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189)
(³Center for Analysis and Testing, Nanjing Normal University, Nanjing 210097)
(⁴College of Chemistry and Environmental Science, Nanjing Normal University, Nanjing 210097)

Received:2011-01-14 Revised:2011-05-17 Published:2011-06-09

The anti-tumor effect of Traditional Chinese Medicine Alisma may be related to the change of protein components in serum. The molecular interaction mechanism of Alisols with Human Serum Albumin (HSA) was investigated by fluorescence and circular dichroism spectra in combination with molecular modeling under the simulated physiological conditions in the paper. Molecular modeling results are in agreement with the experimental results revealed that the binding of Alisol B 23-acetate and HSA was much more stronger than that with Alisol A 24-acetate, indicating that the difference is related to the structure of the side chain. The conclusion should be of great assistant for studying formulations of Alisma and the anti-tumor mechanism.

Key words: alisol B 23-acetate, alisol A 24-acetate, fluorescence spectra, circular dichroism spectra, molecular modeling

Cite this article

XU Fei, ZHANG Lin-Qun, HE Li-Wei, GU Wei, FANG Fang, WU Qi-Nan, ZHAO Bo. Molecular Mechanism on the Interaction between Alisols and Human Serum Albumin[J]. Acta Chimica Sinica, 2011, 69(19): 2228-2234.

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泽泻醇类化合物与血清白蛋白相互作用的分子机理研究

Molecular Mechanism on the Interaction between Alisols and Human Serum Albumin

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