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Acta Chimica Sinica ›› 2011, Vol. 69 ›› Issue (20): 2518-2522. Previous Articles     Next Articles

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芫花花蕾中的两个新二萜

夏素霞1，李玲芝2，李菲菲2，彭缨*,3，宋少江*,2，高品一2，唐思1   

  1. (1辽宁省中医药研究院 沈阳 110034)
    (2沈阳药科大学中药学院 沈阳 110016)
    (3沈阳药科大学药学院 沈阳 110016)
  • 投稿日期:2010-12-10 修回日期:2011-05-10 发布日期:2011-06-28
  • 通讯作者: 宋少江 E-mail:songsj99@163.com
  • 基金资助:

    中药芫花炮制前后物质基础及抗肿瘤活性改变的相关性研究

Two Novel Diterpenes Isolated from the Flower Buds of Daphne genkwa

Xia Suxia1 Li Lingzhi2 Li Feifei 2 Peng Ying*,3 Song Shaojiang*,2 Gao Pinyi2 Tang Si1   

  1. (1 Laboratory of Clinical Pharmacology, Academe of Traditional Chinese Medicine of Liaoning Province, Shenyang 110034)
    (2 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016)
    (3 School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016)
  • Received:2010-12-10 Revised:2011-05-10 Published:2011-06-28

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Daphnane-type diterpenes showed potent anti-tumour activities, the flower buds of Daphne genkwa which was rich in daphnane-type diterpenes were subject to phytochemical investigation resulting in the isolation of two novel diterpenes (1, 2) and a known diterpene 3, they were elucidated as 12-O-(2E,4E-decadienoyl)-4-hydroxyphorbol-13-acetyl (1), isoyuanhuadine (2) and yuanhuadine (3) by spectroscopic data, including 1H NMR, 13C NMR, HSQC, HMBC, NOESY, ESI-MS and HR-ESI-MS. The new compound isoyanhuadine is yuanhuadines cis-isomer.

Key words: the flower buds of Daphne genkwa, structure elucidation, 12-O-(2E,4E-decadienoyl)-4- hydroxyphorbol-13-acetyl, isoyuanhuadine, yuanhuadine