Cellulose-tris(3,5-dimethylphenylcarbamates) (CDMPC) coated on mesoporous silica SBA-15 (SBA@CDMPC) with a high surface area and large pore diameters was applied in chiral high performance liquid chromatography (HPLC). The direct enantioseparation of seven chiral compounds has been achieved using n-hexane/alcohol as the mobile phase. Chromatographic behavior of chiral compounds on SBA@CDMPC was compared with that on CDMPC coated on silica gel (SG@CDMPC) by hexane-isopropanol as the mobile phase. The result suggests that SBA@CDMPC shows high chiral recognition abilities in chiral HPLC. SBA@CDMPC is a suitable chiral stationary phase (CSP) for the optical resolution of a lot of racemates by HPLC.

Key words: SBA-15, cellulose tris-(3,5-dimethylphenylcarbamate), enantioseparation