The syntheses of the three-directional ether-amide bond branched macromolecules utilizing glycerol and nitromethane as three- directional initiator cores were described. Three branched monomers 1- 3, possessing 3-fold symmetry and branches emanating from a tetrahedral carbon branch point, were utilized as the key building block in the dendrimer syntheses. An extended group via ether bond was utilized for the circumvention of the steric crowding in the cores. The title compounds were respectively synthesized with three branched building blocks via amido linkage procedure. In just one and two generations, the number of the functional groups in the exterior layer of the multibranched compounds is thrice and nine-fold as that of initiator cores. The synthesis of the model compounds provides a route to the synthesis of other cascade molecules.

Key words: MACROMOLECULES, AMIDO BOND, ETHER, GLYCEROL, NITROCARBOL, ETHER BOND, AMIDO BOND, SYNTHESIS METHODS