Studies on the constituents of tussilago farfara L. I. Structure of tussilagone

Acta Chimica Sinica ›› 1987, Vol. 45 ›› Issue (5): 450-455. Previous Articles Next Articles

Original Articles

款冬花化学成份的研究I.款冬酮的结构

应百平;杨培明;朱任宏

中国科学院上海药物研究所

发布日期:1987-05-15

Studies on the constituents of tussilago farfara L. I. Structure of tussilagone

YING BAIPING;YANG PEIMING;ZHU RENHONG

Published:1987-05-15

Abstract

A sesquiterpene ester, tussilagone (I) was isolated from the flowers of T. farfara, a Chinese traditional medicine. I structure was determine by NMR and its configuration determine as 3S, 4S, 5S, 7R, 9R and 14R by x-ray diffraction and CD. I is the 1st sesquiterpene isolated from Tussilago. I.v. injection of I caused strong and instant pressor responses in dogs, cats, and rats, with a potency similar to that of dopamine.

Key words: ANTIHYPERTENSIVE AGENTS, CHEMICAL COMPOSITION, ACETIC ACID ESTER, SESQUITERPENE, X-RAY DIFFRACTION ANALYSIS, C13 NMR SPECTROMETRY, CARBOXYLIC ACID ESTER, PROTON MAGNETIC RESONANCE SPECTROMETRY, BENZENECARBOXYLIC ACID P, CIRCULAR DICHROISM

CLC Number:

O629

Cite this article

YING BAIPING;YANG PEIMING;ZHU RENHONG. Studies on the constituents of tussilago farfara L. I. Structure of tussilagone[J]. Acta Chimica Sinica, 1987, 45(5): 450-455.

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款冬花化学成份的研究I.款冬酮的结构

Studies on the constituents of tussilago farfara L. I. Structure of tussilagone

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