Acta Chimica Sinica ›› 1989, Vol. 47 ›› Issue (5): 428-433. Previous Articles     Next Articles

Original Articles

具有生物活性的金属配合物的研究 IV: 3,6-二(二甲氨基)-二苯并碘六环稀土二(氨三乙酸)配合物的合成、性质及抗肿瘤活性

陈淑英;刘展良;侯自杰;李笃;王欣;傅萍;张培   

  1. 兰州大学化学系;兰州医学院药学系
  • 发布日期:1989-05-15

Study on biologically active coordination compounds of metal ions IV: Synthesis, characterization and antitumor activity of rare earth bis(nitrilotriacetate) complexes of 3,6-di(dimethylamino)-dibenzopyriodonium

CHEN SHUYING;LIU ZHANLIANG;HOU ZIJIE;LI DU;WANG XIN;FU PING;ZHANG PEI   

  • Published:1989-05-15

[C17H20N2I]3{RE[N(CH2CO2)3]2}.nH2O (C17H20N2I = 3,6-di(dimethylamino) dibenzopyriodonium; RE = La, Eu, Er, n = 3; RE = Ce-Nd, Tb-Ho, Tm, Yb, Y, n = 4; RE = Sm, Gd, Lu, n = 5) were prepared The complex salts were characterized by x-ray powder diffraction TG-DTA, IR, UV, 1H NMR and molar conductances. The antitumor activity of the La complex was studied on transplanted mouse tumor S180 in vivo and mouse lymphocytic leukemia cell (L1910) in vitro. The results showed that the La complex is more effective than its precursors. The Dy complex is monoclinic, space group P212121, a 1.5154(2), b 1.8234(3), c 2.4010 ? Z = 4, dc = 1.751 g cm-3.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, ANTICARCINOGEN, INFRARED SPECTROPHOTOMETRY, X-RAY DIFFRACTION ANALYSIS, YTTRIUM COMPLEX, NITRILOTRISACETIC ACID P, HOLMIUM COMPLEX, RARE EARTH METAL COMPLEX, CERIUM COMPLEX, THERMOGRAVIMETRY

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