Acta Chimica Sinica ›› 1989, Vol. 47 ›› Issue (9): 884-889. Previous Articles     Next Articles

Original Articles

Vobasine-Aspidosperma型双吲哚生物碱的半合成

黄知恒;郑皎皎;周韵丽   

  1. 中国科学院上海药物研究所
  • 发布日期:1989-09-15

Partial synthesis of vobasine-aspidosperma type bisindole alkaloids

HUANG ZHIHENG;ZHENG JIAOJIAO;ZHOU YUNLI   

  • Published:1989-09-15

Four vobasine-aspidosperma type bisindole alkaloids were prepared by coupling the monomeric counterparts in acidic medium and their structure confirmed by 1H NMR and MS. These new alkaloids, in particular I, showed remarkable antitumor activity to suppress the growth of P-388 cells in vitro.

Key words: ANTICARCINOGEN, MASS SPECTROGRAPHY, INDOLE ALKALOIDS, PROTON MAGNETIC RESONANCE SPECTROMETRY, SYNTHESIS METHODS

CLC Number: