Acta Chimica Sinica ›› 1992, Vol. 50 ›› Issue (5): 498-503. Previous Articles     Next Articles

Original Articles

抗癌药物冬凌草甲素的分子构型研究

杨延武;许肖龙;王德华;钱保功;赵清治;姬昂   

  1. 中国科学院波谱与原子分子物理开放实验室;河南医科大学化学教研室
  • 发布日期:1992-05-15

Studies of molecular configuration of oridonin by 2D-NMR

YANG YANWU;XU XIAOLONG;WANG DEHUA;QIAN BAOGONG;ZHAO QINGZHI;JI ANG   

  • Published:1992-05-15

Two dimensional heteronuclear and homonuclear chem. shift correlation NMR experiments have been used for the complete assignment of all proton chem. shifts of oridonin (I), and the coupling constants of oridonin were measured by one dimensional 1H and 2D-J resolved spectra. The dihedral angles were calculated by using a series of modified Karplus equations. The relative configuration of I was calculated from dihedral angles and standard bond lengths.

Key words: ANTICARCINOGEN, PROTON MAGNETIC RESONANCE SPECTROMETRY, RUBDESCENSINE A, COMPUTER PROGRAM, MOLECULAR CONFIGURATION

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