Theoretical Studies on Shelf-life of 10% Ascorbic Acid Solution

Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (6): 459-465. Next Articles

Original Articles

10%维生素C溶液贮存期的理论研究

封家福王英利詹先成* 罗琳李琳丽李成容

(四川大学华西药学院靶向药物教育部重点实验室成都 610041)

投稿日期:2008-10-21 修回日期:2008-12-09 发布日期:2009-03-28
通讯作者: 詹先成

Theoretical Studies on Shelf-life of 10% Ascorbic Acid Solution

Feng, Jiafu Wang, Yingli Zhan, Xiancheng* Luo, Lin Li, Linli Li, Chengrong

(Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu 610041)

Received:2008-10-21 Revised:2008-12-09 Published:2009-03-28
Contact: Zhan, Xiancheng

Abstract

The rates of two sets of parallel reactions, the degradation reactions of ascorbic acid under both anaerobic and aerobic conditions and the oxidation reactions of ascorbic acid and sodium metabisulfite, were investigated. The results show zero-order for the degradation of ascorbic acid under anaerobic conditions; zero-order with respect to ascorbic acid and sodium metabisulfite for the oxidation reactions of ascorbic acid and sodium metabisulfite, respectively; and first-order with respect‏ to the oxygen concentration in solution. A plot of absorbency versus the total concentration drop of ascorbic acid yields a straight line. The shelf-life of ascorbic acid solution calculated was 444 d (or 152 d) with (or without) sodium metabisulfite, indicating that sodium metabisulfite increases the stability of ascorbic acid significantly.

Key words: ascorbic acid, sodium metabisulfite, rate constant, reaction order, shelf-life

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10%维生素C溶液贮存期的理论研究

Theoretical Studies on Shelf-life of 10% Ascorbic Acid Solution

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