Through encapsulating hydrophobic CdTe nanocrystals, CdTe@P(St-DVB) hybrid fluorescent nanosized modified microspheres were prepared by modified miniemulsion polymerization. High initiator concentration and high crosslinking degree were necessary to inhibit the phase separation of polymer chains with nanocrystals and reserve luminescence. Further more, to make the hybrid microspheres with good dispersibility in aqueous media, 3-(methacryloxy)propyl triethoxysilane (MPS) was added to copolymerize with St and DVB, and after hydrolization the microspheres with silanol groups on the surface were obtained, which can be well dispersed in water and used for cell imaging.

Key words: miniemulsion polymerization, CdTe, fluorescent microsphere