Preparation of Multi-responsive Mesoporous Silica Microspheres and Its Application in Controlled Drug Release

Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (8): 843-849. Previous Articles Next Articles

Original Articles

多重响应性介孔二氧化硅纳米微球的制备及载药研究

刘聪颖胡建华* 杨东杨武利*

(复旦大学高分子科学系聚合物分子工程教育部重点实验室上海 200433)

投稿日期:2009-03-12 修回日期:2009-03-30 发布日期:2009-04-28
通讯作者: 胡建华

Preparation of Multi-responsive Mesoporous Silica Microspheres and Its Application in Controlled Drug Release

Liu, Congying Hu, Jianhua* Yang, Dong Yang, Wuli*

(Education Ministry Key Laboratory of Molecular Engineering of Polymer, Department of Macromolecular Science,
Fudan University, Shanghai 200433)

Received:2009-03-12 Revised:2009-03-30 Published:2009-04-28
Contact: Hu Jian-Hua

Abstract

Magnetic mesoporous silica nanoparticles (M-MSN) were prepared via sol-gel technology with oil stabilized Fe3O4 as the core and cetytrimethylammonium bromide (CTAB) as the template. Then P(NIPAM-co-NHMA) copolymer was modified to the magnetic mesoporous silica nanoparticles to prepare a kind of multi-responsive mesoporous silica microspheres, P(NIPAM-co-NHMA)@M-MSN(-COOH), through chain transfer reaction. Brunauer-Emmett-Teller (BET), vibrating-sample magnetometer (VSM), transmission electron microscopy (TEM) and UV/vis spectra were used to characterize the multi-responsive microspheres. DOX was used as a model drug to measure the drug loading and controlled drug releasing properties. The result indicated that the multi-responsive microspheres exhibited an excellent drug loading capacity of 48% and controlled drug releasing could be obtained by changing the temperature and pH values.

Key words: multi-responsive, mesoporous silica, drug loading, controlled drug releasing

Cite this article

Hu Jian-Hua. Preparation of Multi-responsive Mesoporous Silica Microspheres and Its Application in Controlled Drug Release[J]. Acta Chimica Sinica, 2009, 67(8): 843-849.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Wang Xin, Tan Lili, Yang Yingwei. Controlled Drug Release Systems Based on Mesoporous Silica Capped by Gold Nanoparticles [J]. Acta Chim. Sinica, 2016, 74(4): 303-311.
[2]	Du Fangkai, Xu Jiangsheng, Zeng Fang, Wu Shuizhu. Preparation of a Multifunctional Nano-carrier System Based on Carbon Dots with pH-Triggered Drug Release [J]. Acta Chim. Sinica, 2016, 74(3): 241-250.
[3]	Liu Delong, Lu Danfeng, Zhao Qiao, Chen Chen, Qi Zhimei. Large-area High-performance SERS Substrates Prepared with a Combination of Mesoporous Silica Film and AuAg Alloy film [J]. Acta Chim. Sinica, 2015, 73(1): 41-46.
[4]	Lin Jiehua, Zhang Huihui, Shao Meijia. A Label-free Immunosensor based on Ionic Liquids Modified Mesoporous Silica for Simultaneous Determination of Two Tumor Markers [J]. Acta Chimica Sinica, 2014, 72(2): 241-245.
[5]	Zhang Jianbo, Yang Yuxiang, Tian Meijuan, Deng Changjian, Cao Lei, Yuan Hongming. Synthesis of Worm-like Mesoporous Silica and Enzymatic Activity of the Immobilized Laccase [J]. Acta Chimica Sinica, 2013, 71(04): 602-612.
[6]	Ji Yongjun, Zhang Bin, Zhang Kun, Xu Le, Peng Honggeng, Wu Peng. Core/shell-Structured ZSM-5@Mesoporous Silica Composites for Shape-Selective Alkylation of Toluene with Methanol [J]. Acta Chimica Sinica, 2013, 71(03): 371-380.
[7]	Zhang Wenjian, Fan Wei, Li Min, Hong Chunyan, Pan Caiyuan. Multi-responsive Hyperbranched Star Copolymer: Synthesis, Self-assembly and Controlled Release [J]. Acta Chimica Sinica, 2012, 70(16): 1690-1696.
[8]	LI Meng, YU Jian-Chang. Synthesis and Phase Transition of Ordered Mesoporous Carbon [J]. Acta Chimica Sinica, 2011, 69(02): 226-230.
[9]	TANG Qian-Qian, YUAN Li, YANG Dong, HU Jian-Hua. Preparation and Characterization of Disulfide Bond Functionalized Mesoporous Silica Microspheres [J]. Acta Chimica Sinica, 2010, 68(18): 1925-1929.
[10]	YIN An-Yuan, GUO Xiao-Yang, DAI Wei-Lin-*, FAN Kang-Nian. Textural Structure Effect of SiO₂ on the Catalytic Performance for Hydrogenation of Dimethyl Oxalate to Ethylene Glycol over Different Cu-based Catalysts [J]. Acta Chimica Sinica, 2010, 68(13): 1285-1290.
[11]	. Adsorption Behavior of NPE on Ordered Mesoporous Carbons [J]. Acta Chimica Sinica, 2009, 67(2): 1771-1778.
[12]	. Adsorption Studies of Phe on Super-hydrophobic Organic-inorganic Hybrid Mesoporous Silica [J]. Acta Chimica Sinica, 2009, 67(15): 1754-1758.
[13]	. Adsorption Behavior of NPE on Ordered Mesoporous Carbons [J]. Acta Chimica Sinica, 2009, 67(15): 1771-1778.
[14]	. Synthesis of Mesoporous Silica Single Crystal of Rhombic Dodecahedron Using Tri-head Group Quarternary Ammonium Cationic Surfactant [J]. Acta Chimica Sinica, 2009, 67(10): 1093-1097.
[15]	CAI Jie REN Nan² TANG Yi² YANG Wu-Li*^,1. Preparation and Property of the Mesoporous Silica Microspheres Embedded with Quantum Dots [J]. Acta Chimica Sinica, 2008, 66(8): 923-929.

多重响应性介孔二氧化硅纳米微球的制备及载药研究

Preparation of Multi-responsive Mesoporous Silica Microspheres and Its Application in Controlled Drug Release

PDF

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments