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Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (9): 974-982. Previous Articles     Next Articles

Original Articles

(E)-N-芳基-3-[2-(8-羟基喹啉基)-乙烯基]咔唑的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究

王光荣a 李熙灿b 曾和平*,a

  

  1. (a华南理工大学化学科学学院功能分子研究所 广州 510641)
    (b广州中医药大学 广州 510405)

  • 投稿日期:2008-11-20 修回日期:2008-12-26 发布日期:2009-05-14
  • 通讯作者: 曾和平

Synthesis, Antioxidation Activity of (E)-9-p-Tolyl-3-[2-(8-hydroxy-quinol-2-yl)vinyl]-carbazole and (E)-9-(p-Anisyl)-3-[2-(8-hydroxy-quinol-2-yl)vinyl]-carbazole and Their Induction Proliferation of Mesenchymal Stem Cells

Wang, Guangrong a Li, Xican b Zeng, Heping *,a   

  1. (a Institute of Functional Molecule, School of Chemistry, South China University of Technology, Guangzhou 510641)
    (b Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405)
  • Received:2008-11-20 Revised:2008-12-26 Published:2009-05-14
  • Contact: Zeng, Heping

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(E)-9-p-Tolyl-3-[2-(8-hydroxyquinol-2-yl)vinyl]-carbazole (8) and (E)-9-(p-anisyl)-3-[2-(8-hydroxyquinol-2-yl)vinyl]-carbazole (9) have been synthesized and confirmed by UV-Vis, FT-IR, MS, 1H NMR and elemental analysis. Meanwhile, the antioxidation activity and stem cell activity of the title compounds have been investigated by the DPPH•, , HO• and MTT methods, showing that the title compounds have strong antioxidation activity, and compound 9 can induce effectively the proliferation of mesenchymal stem cells under a low concentration condition.

Key words: (E)-9-p-tolyl-3-[2-(8-hydroxyquinol-2-yl)vinyl]-carbazole, (E)-9-(p-anisyl)-3-[2-(8-hydroxy- quinol-2-yl)vinyl]-carbazole, antioxidation activity, proliferation of mesenchymal stem cell