The adsorption and oxidation of polyadenylic acid [Poly(A)] was studied by means of microelectrode cyclic voltammetry and adsorptive transfer stripping voltammetry (AdTSV). The results show that there exist a significant difference between the voltammograms of Poly(A) adsorpted with adenine residues and those of it with phosphate residues. The former showed several strong redox peaks near 0.0V (vs. Ag/AgCl). While the latter showed no redox peak in the scan ranges. In addition, three adsorption modes of Poly(A) at gold electrode were suggested based on the voltammograms.

Key words: NUCLEIC ACIDS, MICROELECTRODE, CYCLOVOLTAMGRAPH