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Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (10): 1123-1126. Previous Articles     Next Articles

Original Articles

牛蒡苷元的生物转化及电喷雾质谱研究

赵宇峰a,b 宋凤瑞b 赵立平a 刘淑莹*,b

  

  1. (a上海交通大学系统生物医学研究院 上海 200240)
    (b中国科学院长春应用化学研究所长春质谱中心 长春 130022)

  • 投稿日期:2008-04-01 修回日期:2008-12-08 发布日期:2009-05-28
  • 通讯作者: 刘淑莹

Studies on the Biotransformation of Arctigenin Using Electrospray Ionization Mass Spectrometry

Zhao, Yufeng a,b Song, Fengrui b Zhao, Liping a Liu, Shuying *,b   

  1. (a Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240)
    (b Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022)
  • Received:2008-04-01 Revised:2008-12-08 Published:2009-05-28
  • Contact: Liu, Shuying

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To study the biotransformation of arctigenin, arctigenin was anaerobically incubated with Eubacterium sp. ARC-2 of human intestinal bacteria in vitro. Arctigenin formed a molecular ion [M－H]－ in negative ion mode. The arctigenin and its metabolites were investigated directly by the electrospray ionization tandem mass spectrometry ion trap and Fourier transform ion cyclotron resonance. Arctigenin was transformed to 4’,4’’-dihydroxylenterolactone by E sp. ARC-2 through 3 types of demethylation products.

Key words: arctigenin, Eubacterium sp. ARC-2, biotransformation, electrospray ionization mass spectrometry, 4’,4’’-dihydroxylenterolactone