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Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (16): 1654-1656. Previous Articles     Next Articles

Original Articles

四氢噻唑-2-硫酮用于赖氨酸侧链选择性保护反应

高兴明, 叶蕴华*   

  1. (北京大学化学与分子工程学院 教育部生物有机化学与分子工程重点实验室 北京 100871)
  • 投稿日期:2007-03-28 修回日期:2007-06-20 发布日期:2007-08-28
  • 通讯作者: 叶蕴华

Application of Tetrahydrothiazole-2-thione (TTT) in the Reaction of Selective Side Chain Protection of Lysine

GAO Xing-Ming; YE Yun-Hua*   

  1. (The Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871)
  • Received:2007-03-28 Revised:2007-06-20 Published:2007-08-28
  • Contact: YE Yun-Hua

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A lysine derivative with selectively protected side chain Na-Boc-Ne-Fmoc-L-Lys-OH was synthesized through decomposition of lysine cupric complex with tetrahydrothiazole-2-thione (TTT). The results indicate that the decomposition is faster and more complete, the by-product was easier to be removed than that with traditional reagents (H2S, EDTA, HCl).

Key words: tetrahydrothiazole-2-thione (TTT), lysine derivative, amino acid-cupric complex