Three New Eremophilane-Type Sesquiterpenes from Ligularia macrophylla

Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (16): 1638-1642. Previous Articles Next Articles

Original Articles

大叶橐吾中三个新的艾里莫芬型倍半萜

沈彤, 李平林, 袁呈山*, 贾忠建*

(兰州大学化学化工学院功能有机分子化学国家重点实验室兰州 730000)

投稿日期:2007-04-04 修回日期:2007-07-05 发布日期:2007-08-28
通讯作者: 袁呈山, 贾忠建

Three New Eremophilane-Type Sesquiterpenes from Ligularia macrophylla

SHEN Tong; LI Ping-Lin; YUAN Cheng-Shan*; JIA Zhong-Jian*

(State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000)

Received:2007-04-04 Revised:2007-07-05 Published:2007-08-28
Contact: YUAN Cheng-Shan; JIA Zhong-Jian

Abstract

Three new eremophilane-type sesquitererpenes (1, 2 and 3) were isolated from the roots of Ligularia macrophylla. On the basis of spectroscopic methods including 2D NMR and X-ray diffraction experiment, their structures were elucidated as 6α,15β-epoxy-8β-hydroxy-7(11)-8α,12-olide (1), 7-acetyl-6(7)-en-nor- eremophil-13β-carboxylic acid (2) and eremophil-7(11)-en-6α,15β-olide (3). In addition, antibacterial activity and cytotoxicity activity of compound 1 were tested.

Key words: Ligularia macrophylla, Compositae, eremophilane-type sesquiterpene, X-ray diffraction

Cite this article

SHEN Tong; LI Ping-Lin; YUAN Cheng-Shan*; JIA Zhong-Jian*. Three New Eremophilane-Type Sesquiterpenes from Ligularia macrophylla[J]. Acta Chimica Sinica, 2007, 65(16): 1638-1642.

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大叶橐吾中三个新的艾里莫芬型倍半萜

Three New Eremophilane-Type Sesquiterpenes from Ligularia macrophylla

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