(＋)-Disparlure is the sex attractant emitted by the female gypsy moth. Because of the growing demand for pest control, many syntheses of (＋)-disparlure have been reported. The concise and efficient asymmetric total synthesis of (＋)-disparlure was accomplished, starting from undecanal and cyclopentanone by using L-proline-catalyzed asymmetric aldol reaction to construct the chiral lactone, then by Baeyer-Vil-liger oxidation and Wittig olefination, providing a new strategy on the synthesis of (＋)-(7R,8S)-cis-7,8-epoxy-2-methyloctadecane in a total yield of 37.8%.

Key words: (＋)-disparlure, L-proline-catalyzed aldol reaction, Baeyer-Villiger oxidation, Wittig olefination