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Acta Chimica Sinica ›› 2009, Vol. 67 ›› Issue (21): 2439-2444. Previous Articles     Next Articles

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乌头碱在家兔肠道内代谢产物的LC/ESI-MSn研究

随志刚a,d    姜雅秋b    刘志强c    梁 峰a    闫 峻a    刘忠英*,a   

  1. (a吉林大学药学院 长春 130021) (b吉林大学第一医院 长春 130021) (c中国科学院长春应用化学研究所 长春 130022) (d吉林大学白求恩医学院 长春 130021)
  • 投稿日期:2009-02-12 修回日期:2009-06-16 发布日期:2009-07-01
  • 通讯作者: 刘志强 E-mail:liuzq@ciac.jl.cn
  • 基金资助:

    国家自然科学基金(30873360)资助

Study on Metabolites of Aconitine in Rabbit Intestines by Using LC/ESI-MSn

Sui, Zhigang a,d   Jiang, Yaqiub    Liu, Zhiqiangc    Liang, Fenga    Yan, Juna    Liu, Zhongying*,a   

  1. (a College of Pharmaceutical, Jilin University, Changchun 130021) (b The First Hospital of Jilin University, Changchun 130021) (c Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022) (d Norman Bethune College of Medicine, Jilin University, Changchun 130021)
  • Received:2009-02-12 Revised:2009-06-16 Published:2009-07-01

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LC/ESI-MSn was used to separate and determine the major metabolites of aconitine in intestines of rabbit. Compared with the control samples, six compounds (M1～M6) were found in small intestine, five compounds (M2～M6) in caecum and two compounds (M3, M4) in feces. On the bases of MSn fragmentation of standard and references, they were deduced as 16-O-demethyl-8-O-deacetylaconitine (M1), 8-O-deacetylaconitine (M2), 16-O-demethylaconitne (M3), aconitine (M4), deoxyaconitine (M5) and indaconitine (M6).

Key words: aconitine (AC), metabolites, LC/ESI-MSn