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Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (23): 2731-2737. Previous Articles     Next Articles

主客体包结法选择分离青花椒挥发油中的化学成分

郭文生*,1, 王忠华1, 郭放1, 胡志泉1, 张爽1, 徐赫男2,3, 常键4, 刘成雁4   

  1. (1辽宁大学化学科学与工程学院 沈阳 110036)
    (2郑州大学化学系 郑州 450052)
    (3沈阳药科大学制药工程学院 沈阳 110015)
    (4辽宁省分析测试研究院 沈阳 110015)
  • 投稿日期:2007-01-18 修回日期:2007-08-06 发布日期:2007-12-14
  • 通讯作者: 郭文生

Selective Isolation of Components of Volatile Oil of Zanthoxylum Schinifolium Sieb.et Zucc Using Inclusion Crystallization of Host and Guest

GUO Wen-Sheng*,1; WANG Zhong-Hua1; GUO Fang1; HU Zhi-Quan1; ZHANG Shuang1; XU He-Nan2,3; CHANG Jian4; LIU Cheng-Yan4   

  1. (1 Institute of Chemical Science & Engineering, Liaoning University, Shenyang 110036)
    (2 Department of Chemistry, Zhengzhou University, Zhengzhou 450052)
    (3 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110015)
    (4 Liaoning Provincial Institute of Analysis Testing and Research, Shenyang 110015)
  • Received:2007-01-18 Revised:2007-08-06 Published:2007-12-14
  • Contact: GUO Wen-Sheng

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1,1,6,6-Tetraphenylhexa-2,4-diyne-1,6-diol as host could selectively isolate 4-allylanisole from the crude volatile oil of Zanthoxylum schinifolium Sieb.et Zucc simply and rapidly , with a yeild of 3.78% based on the amount of volatile oil used. Inclusion compound structure was confirmed by IR, 1H NMR, 13C NMR and single crystal X-ray diffraction. Gas chromatographic method was used to assess the isolation effect and gas chromatographic purity of 4-allylanisole separated is 94.5%. At the same time, the channel framework formed by hosts could recognize p-anisaldehyde and form exceptive structural inclusion compound at a molar ratio of 2∶1 (host/guest), which is a supramolecular isomer of inclusion compound at a molar ratio of 1∶2 (host/guest).

Key words: Zanthoxylum schinifolium Sieb.et Zucc, inclusion compound, selective isolation, 4-allylanisole, p-anisaldehyde