Relevancy of Relaxation Rate and Chemical Shift of Imaging Molecules to the Molecular-weight and Concentration of Magnevist

Acta Chimica Sinica ›› 2007, Vol. 65 ›› Issue (24): 2971-2975. Previous Articles

成像核弛豫速率和化学位移与其分子量大小和钆喷酸浓度的相关性

俞开潮¹, 肖立平¹, 周锦兰*^{,1, 丁尚武²}

(¹华中科技大学化学与化工系生物无机化学与药物湖北省重点实验室武汉 430074)
(²中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室武汉 430071)

投稿日期:2006-12-25 修回日期:2007-05-31 发布日期:2007-12-28
通讯作者: 周锦兰

Relevancy of Relaxation Rate and Chemical Shift of Imaging Molecules to the Molecular-weight and Concentration of Magnevist

YU Kai-Chao¹; XIAO Li-Ping¹; ZHOU Jin-Lan*^{,1; DING Shang-Wu²}

(¹ Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074)
(² State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071)

Received:2006-12-25 Revised:2007-05-31 Published:2007-12-28
Contact: ZHOU Jin-Lan

Abstract

An enhancement of the relaxation rates and chemical shift change of imaging nuclei introduced by Magnevist, a mostly used magnetic resonance imaging (MRI) gadolinium contrast agent, was observed. The relaxation enhancement and chemical shift change depend on the size of the molecule where the imaged nuclear species is located and the concentration of Magnevist: the small molecules (water) show a perfect linear relationship between the concentration and the chemical shift change or relaxation enhancement while the macromolecules (PEG-2000 and PEG-6000) show a pronounced nonlinear effect.

Key words: magnetic resonance imaging contrast agent, relaxation, chemical shift, macromolecule

Cite this article

YU Kai-Chao; XIAO Li-Ping; ZHOU Jin-Lan*^,1; DING Shang-Wu^{2. Relevancy of Relaxation Rate and Chemical Shift of Imaging Molecules to the Molecular-weight and Concentration of Magnevist[J]. Acta Chimica Sinica, 2007, 65(24): 2971-2975.}

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成像核弛豫速率和化学位移与其分子量大小和钆喷酸浓度的相关性

Relevancy of Relaxation Rate and Chemical Shift of Imaging Molecules to the Molecular-weight and Concentration of Magnevist

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