Isolation and structures of schisantherin J and schisanlactione F

Abstract

One new lignan, schisantherin J(I) and one new triterpenoid, schisanlactone F (II) were isolated along with four known compounds, schisanlactone A, schizandronic acid, epianwuweizic acid and di-Me deangeloyl schisantherin F, from the seed of Kadsura longipeduaculata Finet. et Gagnep. Their structures including absolute configurations were elucidated by spectroscopic studies and chem. conversions. In anticancer screening, II shows a significant inhibition of leukemia P-388 cells in vitro (ED50 5 mg/mL).

Key words: LACTONES, ESTERS, ANTICARCINOGEN, MOLECULAR STRUCTURE, ANTI-LEUKAEMIA DRUG, SCHISANDRA CHINENSIS

CLC Number:

O629

Cite this article

LIU JIASEN;PAN YANPING. Isolation and structures of schisantherin J and schisanlactione F[J]. Acta Chimica Sinica, 1991, 49(3): 308-312.

Export EndNote|Reference Manager|ProCite|BibTeX|RefWorks

[1]	Li Liu, Gang Zheng, Guoqiang Fan, Hongguang Du, Jiajing Tan. Research Progress in Organic Reactions Involving 4-Acyl/Carbamoyl/Alkoxycarbonyl Substituted Hantzsch Esters [J]. Acta Chimica Sinica, 2023, 81(6): 657-668.
[2]	Xiaochen Wang, Zeyao Ji, Jian Liu, Bingfu Wang, Hui Jin, Lixin Zhang. Advances in Organocatalytic Asymmetric Reactions Involving Thioesters [J]. Acta Chimica Sinica, 2023, 81(1): 64-83.
[3]	Hongshao Jia, Baokun Qiao, Zhiyong Jiang. Photoredox Catalytic Radical Coupling to Access β-Fluoro α-Amino Acid Derivatives [J]. Acta Chimica Sinica, 2021, 79(12): 1477-1480.
[4]	Zhou Yuanchun, Zhou Zhi, Du Wei, Chen Yingchun. Asymmetric Inverse-Electron-Demand Diels-Alder Reaction of 2-Pyrone and 2,5-Dienones via HOMO-Activation [J]. Acta Chim. Sinica, 2018, 76(5): 382-386.
[5]	Liu Mingli, Wu Qi, Shi Huifang, An Zhongfu, Huang Wei. Progress of Research on Organic/Organometallic Mechanoluminescent Materials [J]. Acta Chim. Sinica, 2018, 76(4): 246-258.
[6]	Cai Zhongjian, Lu Xinmou, Wang Shunyi, Ji Shunjun. Copper-Catalyzed Cyclization of Oxime Acetates with 2-Benzylidenemalononitriles for Synthesis of 2?Aminonicotinonitriles [J]. Acta Chimica Sinica, 2014, 72(8): 914-919.
[7]	Xie Chengwei, Bai Song, Song Baoan, Yang Song. Study of Mechanism to Asymmetric Mannich Reaction of Diethyl Malonate and Benzothiazol Imine Catalyzed by Applying Chiral Quinidine [J]. Acta Chimica Sinica, 2013, 71(9): 1301-1306.
[8]	Wang Kang, Wang Hailong, Mack John, Li Wenjun, Kobayashi Nagao, Jiang Jianzhuang. Chiral Phthalocyanine with Unambiguous Absolute Molecular Structures for Both Enantiomers [J]. Acta Chimica Sinica, 2012, 70(17): 1791-1797.
[9]	Li Ming, Li Zaijun, Li Guanyan, Chen Linjie, Wang Lina, Jiang Cuicui, Li Lulu, Zhang Zhuangtai. Symmetrical 1,3-Dialkylimidazolium Ionic Liquid Based Single-Drop Microextraction Coupled to GC-MS for the Determination of Esters in Natural Flavors [J]. Acta Chimica Sinica, 2012, 70(15): 1625-1630.
[10]	Wang Qiong, Ma Haixia, Li Jizhen, Wei Hongjian, Fan Xuezhong. Theoretical Studies on the Relationships between Molecular Structure or Thermodecomposition Parameters and Impact Sensitivity of Azotetrazolate Nonmetallic Salts [J]. Acta Chimica Sinica, 2012, 70(05): 629-634 .
[11]	Li Xiaolei, Jiang Pingping, Lu Yun, Zhang Weijie, Dong Yuming. Synthesis of Hydrotalcite-like Compounds Intercalated by 12- Phosphorus Tungsten Heteropoly Acid and Catalytic Performance on the Epoxidation of Fatty Acid Methyl Esters [J]. Acta Chimica Sinica, 2012, 70(05): 544-550 .
[12]	LI Mei-Rong, CAI Xiao-Qing, ZHU Yi-Feng, LIU Kuan-Guan, HU Mao-Lin. Synthesis and Biological Evaluation of Novel Coupling Derivatives of Photosensitizer and 5-fluorouracil as Antineoplastic Agents [J]. Acta Chimica Sinica, 2011, 69(04): 425-430.
[13]	CHOU Ming-Hua, XIE Wen-Lin, LIU Feng-Ping, CHEN Dong-Chu. A New Method of 3D-QSAR Anlysis for Carbonic Anhydrase II Inhibitors [J]. Acta Chimica Sinica, 2010, 68(24): 2581-2589.
[14]	LIU Wan-Qiang, CAO Chen-Zhong. QSPR Study of Normal Boiling Point of Aliphatic Esters Based on the Polarizability Effect Index [J]. Acta Chimica Sinica, 2010, 68(23): 2401-2408.
[15]	DIAO Dun, XU Da-Hai, CHENG Xin-Lu, YANG Xiang-Dong, SHU Zheng-He. Structure and Potential Energy Function of the Ground State of KH (KD) Molecule [J]. Acta Chimica Sinica, 2010, 68(06): 461-465.

五味子酯J和五内酯F的分离与结构