In this article, the silca modified with maleic anhydride was synthesized as carrier material. Then, Molecularly imprinted polymers (MIP) based on surface-modified silica gel were prepared by redox polymerization of acrylamide and N, N’-methylene bisacrylamide as the functional monomer and the crosslinker in the present of bovine hemoglobin as template molecule. The results of IR and scanning electron microscope (SEM) demonstrated the formation of a grafting polymer layer on the modified silica gel surface. The adsorption studies also showed the imprinted polymers had good adsorption capacity and specific recognition for bovine hemoglobin in aqueous solution.

Key words: Surface-modified molecularly imprinted polymer, Bovine hemoglobin, grafting of silica gel, redox polymerization