Four novel polyoxometalates constructed from amantadine and a series of polyoxometalates [1∶10 (Ln∶W) and 1∶13 (Ni or Mn∶V)], which can be formulated as K₄(C₁₀H₁₈N)₅CeW₁₀O₃₆•2H₂O (APOM-5), K₄(C₁₀H₁₈N)₅PrW₁₀O₃₆•2H₂O (APOM-6), K₃(C₁₀H₁₈N)₄NiV₁₃O₃₈•H₂O (APOM-12) and K₃(C₁₀H₁₈N)₄MnV₁₃O₃₈•H₂O (APOM-13) respectively, have been synthesized and characterized by elemental analysis, IR and ¹H NMR spectroscopy methods. The antivirus activity of the synthesized compounds was investigated on the inhibitory effect against both influenza types A and B in Madin-Darby canine kidney (MDCK). It indicates that APOM-13 had significant inhibitory activity against both A and B and APOM-12 had inhibitory activity against both A and B only in high concentration but it was not remarkable in low concentration. APOM-5 and APOM-6 have effectively activity against influenza A but not significantly towards B. In addition, it was found that APOM-12 and APOM-13 exhibited good inhibitory effect on MDCK cytopathogenic effect (CPE) that was infected with influenza virus and the inhibitory activity was more evident in higher concentration.

Key words: amantadine, polyoxometalate, anti-influenza virus activity