Acta Chimica Sinica ›› 1983, Vol. 41 ›› Issue (5): 425-433. Previous Articles     Next Articles

Original Articles

青蒿乙素的化学转化

盖元珠;郑亚平;李良泉   

  1. 中国科学院上海药物研究所
  • 发布日期:1983-05-15

Chemical transformations of arteannuin B

GAI YUANZHU;ZHENG YA PING;LI LIANGQUAN   

  • Published:1983-05-15

Using arteannuin B (2) isolated from Artemisia annua L as a starting material, a number of chemical transformations have been carried out: i.e. catalytic hydrogenation of 2 to give a mixture of 5, 6 and 7, reaction of 6 with boron trifluoride etherate gives 8 and 9, saponification of 6 with postassium hydroxide and deoxygenation of 2, 6 and 7 with iron pentacarbonyl gives 18, 4, and 3 respectively.

Key words: ANTIMALARIALS, ARTEANNUIN, CHEMICAL CHANGE

CLC Number: