In this work, thirty-one rare earth salts of clofenamic acid and indomethacine (nonsteroidal anti-inflammatory drugs) have been prepared in sodium acetate-methanol solution. The composition of these new compounds has been determined as Ln (Ch)3,nH2O, Ce(Ch)4.H2O and Ln(Ind)3.mH2O (where Ln=rare earth ions, HCh=elofe-namic acid, HInd=indomentacine, n=1-2, m=3-5) by the ethods of UV, IR spectra, X-ray powder diffraction, TG curves and electric conductance. Their solubilities in different solvents were investigated. The animal tests showed that the toxicity of these rare earth salts is less than that of the corresponding chlorides.

Key words: AMINO GROUP, INDOCIN, TOXICITY, BENZENECARBOXYLIC ACID P, ORGANO CHLORIDE COMPOUNDS, RARE EARTH COMPOUNDS, ANALGESICS ANTI-INFLAMMATORY