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Acta Chimica Sinica ›› 1996, Vol. 54 ›› Issue (8): 826-832. Previous Articles
Original Articles
孙小玲;吴毓林
发布日期:
SUN XIAOLING;WU YULIN
Published:
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(2E)-4, 5-O-Isopropylidene-pentenylic ester (5), obtained in 3 steps from D-mannitol, was subjected to a series of reactions such as asymmetric dihydroxidation, cyclic sulfation and regioselective opening of the cyclic sulfate by NaN3 and finally was transformed into the 2, 3-dibenzoate of (2S, 3R)-sphingosine. The overall yield from D- mannitol was 7.7%. This work has opened a new route to the synthesis of sphingosine and other sphingolipids.
Key words: INFRARED SPECTROPHOTOMETRY, MASS SPECTROGRAPHY, NMR SPECTROMETRY, MANNITE (=MANNITOL)
CLC Number:
O621
SUN XIAOLING;WU YULIN. The synthesis of (2S, 3R)-sphingosine from D-mannitol[J]. Acta Chimica Sinica, 1996, 54(8): 826-832.
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