Novel angiotensin converting enzyme inhibitors:  Synthesis and structure-activity relationship of azatripeptide analogs

Acta Chimica Sinica ›› 1998, Vol. 56 ›› Issue (7): 707-713. Previous Articles Next Articles

Original Articles

新型血管紧张素转化酶抑制剂: 氮杂三肽类似物的合成及结构活性关系

刘世峰;徐杰诚

中国科学院上海有机化学研究所

发布日期:1998-07-15

Novel angiotensin converting enzyme inhibitors: Synthesis and structure-activity relationship of azatripeptide analogs

LIU SHIFENG;XU JIECHENG

Published:1998-07-15

Abstract

A series of azatripeptide analogs were designed and synthesized. The in vitro inhibitory activities of these compounds toward angiotensin converting enzyme (ACE) were evaluated. Furthermore, the structure-activity relationship of these compound was discussed. The results showed that azaalanine was a good isosterer of alanine in angiotensin converting enzyme inhibitors.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, ANTIHYPERTENSIVE AGENTS, ELEMENTAL ANALYSIS, PROTON MAGNETIC RESONANCE SPECTROMETRY

CLC Number:

R914

Cite this article

LIU SHIFENG;XU JIECHENG. Novel angiotensin converting enzyme inhibitors: Synthesis and structure-activity relationship of azatripeptide analogs[J]. Acta Chimica Sinica, 1998, 56(7): 707-713.

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新型血管紧张素转化酶抑制剂: 氮杂三肽类似物的合成及结构活性关系

Novel angiotensin converting enzyme inhibitors: Synthesis and structure-activity relationship of azatripeptide analogs

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