Acta Chimica Sinica ›› 2001, Vol. 59 ›› Issue (2): 257-261. Previous Articles     Next Articles

Original Articles

带电溶质在电色谱中柱内富集方法的研究-----基本理论 模型和实验验证

张维冰;张博;朱军;张玉奎   

  1. 中国科学院大连化学物理研究所.大连(116012);中国科学院国家色谱研究分析 中心
  • 发布日期:2001-02-15

Study on on- column concentration of ionic sample in capillary electrochromatography ----model development and investigation

Zhang Weibing;Zhang Bo;Zhu Jun;Zhang Yukui   

  1. Dalian Inst Chem Phys, CAS.Dalian(116012)
  • Published:2001-02-15

Concentration process of ionic sample in capliary electrochromatography (CEC) could be carried out through association of separation mechanism of HPLC and capillary electrophoresis. A model was developed to study the concentration process in CEC. The results show that high resistivity sample, with high organic modifier concentration, could result in excelent concentration performance. A basic drug propatene was chosen at testing sample, which provide over 17, 000 times of concentration. This proves the feasibility of the association mechanism of HPLC and capillary electrophoresis. Effects of operation conditions on concentration performance were also studied.

Key words: HIGH SPEED LIQUID CHROMATOGRAPHY, SOLUTE, CONCENTRATION, RELAXATION, CHARGED PARTICLE, DRUGS

CLC Number: