Study on the Preparation and the Biological Activity of Nano Chitosan-oligosaccharide/Fe Complex

Acta Chimica Sinica ›› 2006, Vol. 64 ›› Issue (15): 1570-1574. Previous Articles Next Articles

Original Articles

纳米壳寡糖-铁配合物的制备及其生物活性的研究

黄进, 汪世龙*, 孙晓宇, 张蕤, 姚思德

(同济大学生命科学与技术学院上海 200092)

投稿日期:2005-10-28 修回日期:2006-01-25 发布日期:2006-08-14
通讯作者: 汪世龙

Study on the Preparation and the Biological Activity of Nano Chitosan-oligosaccharide/Fe Complex

HUANG Jin, WANG Shi-Long*, SUN Xiao-Yu, ZHANG Rui, YAO Si-De

(School of Life Science and Technology, Tongji University, Shanghai 200092)

Received:2005-10-28 Revised:2006-01-25 Published:2006-08-14
Contact: WANG Shi-Long

Abstract

The nano chitosan-oligosaccharide/Fe complex was prepared by addition of FeCl₃ to chitosan-oligosaccharide solution, the molecular weight of which was about 5000. The complex was characterized by FTIR, UV spectra and DTA, TEM and PCS method. It was concluded that the Fe(III) was coordinated with the NH₂ of chitosan-oligosaccharide. And the ultraviolet spectroscopy analysis and gel electrophoresis analysis were used to research the biological activity of chitosan-oligosaccharide and chitosan-oligosaccharide/Fe complex via plasmid DNA. The result indicated that the chitosan-oligosaccharide/Fe complex had a strong binding affinity with DNA and the complex could damage and degrade DNA.

Key words: chitosan-oligosaccharide, chitosan-oligosaccharide/Fe complex, plasmid DNA, ultraviolet spectroscopy analysis, gel electrophoresis analysis, biological activity

Cite this article

HUANG Jin, WANG Shi-Long*, SUN Xiao-Yu, ZHANG Rui, YAO Si-De. Study on the Preparation and the Biological Activity of Nano Chitosan-oligosaccharide/Fe Complex[J]. Acta Chimica Sinica, 2006, 64(15): 1570-1574.

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纳米壳寡糖-铁配合物的制备及其生物活性的研究

Study on the Preparation and the Biological Activity of Nano Chitosan-oligosaccharide/Fe Complex

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