Acta Chimica Sinica ›› 1999, Vol. 57 ›› Issue (5): 522-526. Previous Articles     Next Articles

Original Articles

石杉碱甲类拟物的合成及药理研究1: (±)-14-氟石杉碱甲

曾繁星;蒋华良;杨玉社;刘东祥;陈建忠;唐希灿;刘静;沈竞康;陈凯先 ;嵇汝运   

  1. 中国科学院上海药物研究所.上海(200031)
  • 发布日期:1999-05-15

Syntheses and pharmacological studies of huperzine A analogues 1: ( ±)-14-fluorohuperzine A

Zeng Fanxing;Jiang Hualiang;Yang Yushe;Liu Dongxiang;Chen Jianzhong;Tang Xican;Liu Jing;Shen Jingkang;Chen Kaixian;Ji Ruyun   

  1. Shanghai Inst Mat Med., CAS.Shanghai(200031)
  • Published:1999-05-15

The synthesis of (±)-14-fluorohuperzine A (6) has been accomplished and the activity of this agent to inhibit the activity of acetylcholinesterase has been measured. Taking into account its racemic form, this compound is 62 times less potent than that of natural (-)-huperzine A.

Key words: FLUORINATION, ACETYLCHOLINESTERASE, BIOLOGICAL ACTIVITY, INHIBITOR, SENILE DEMENTIA

CLC Number: