Controlled Drug Release from Silk Fibroin Films Treated with Methanol-water Mixtures

doi:10.6023/A1107051

Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (06): 714-720.DOI: 10.6023/A1107051 Previous Articles Next Articles

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甲醇-水混合溶剂后处理制备丝素蛋白膜及其药物释放研究

韦俏娜, 马林, 黄爱民, 杨华, 龚珠萍, 强盼盼, 张丽

广西大学化学化工学院南宁 530004

投稿日期:2011-07-05 修回日期:2011-11-16 发布日期:2011-12-09
通讯作者: 马林
基金资助:
国家自然科学基金(No. 21063002), 广西自然科学基金(No. 2011jjC30004)和广西研究生创新计划(No. 105931003028)资助项目.

Controlled Drug Release from Silk Fibroin Films Treated with Methanol-water Mixtures

Wei Qiaona, Ma Lin, Huang Aimin, Yang Hua, Gong Zhuping, Qiang Panpan, Zhang Li

College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004

Received:2011-07-05 Revised:2011-11-16 Published:2011-12-09
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21063002), Natural Science Foundation of Guangxi Province (No. 2011jjC30004) and Post-graduate Innovation Program of Guangxi Province (No. 105931003028).

Silk fibroin (SF) films were prepared using a casting method and the structural change owing to treatment with methanol-water mixtures of different concentrations was investigated by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The results were used to reveal the influence of structure on the release dynamics of Rhodamine B, a model compound loaded in the SF matrix. In methanol concentration ranging from 50% to 90%, the content of silk Ⅱ crystalline structure, constituted by β-sheet, first increased and then decreased with increasing methanol concentration in the mixtures, reaching a maximum around 80%. It was found that Rhodamine B released from the SF film via Fickian mechanism, of which the diffusional exponent increased with increasing β-sheet content in the matrix, suggesting that the silk Ⅱ crystal could be used as natural regulator for drug release from SF material.

Key words: silk fibroin, controlled release, structural change

Cite this article

Wei Qiaona, Ma Lin, Huang Aimin, Yang Hua, Gong Zhuping, Qiang Panpan, Zhang Li. Controlled Drug Release from Silk Fibroin Films Treated with Methanol-water Mixtures[J]. Acta Chimica Sinica, 2012, 70(06): 714-720.

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References

1 Wenk, E.; Meinel, A. J.; Wildy, S.; Merkle, H. P.; Meinel, L. Biomaterials 2009, 30, 2571.

2 Uebersax, L.; Mattotti, M.; Papaloïzos, M.; Merkle, H. P.; Gander, B.; Meinel, L. Biomaterials 2007, 28, 4449.

3 Karageorgiou, V.; Meinel, L.; Hofmann, S.; Malhotra, A.; Volloch, V.; Kaplan, D. L. J. Biomed. Mater. Res. 2004,71A, 528.

4 Uebersax, L.; Merkle, H. P.; Meinel, L. J. Controlled Release2008, 127, 12.

5 Lovett, M.; Cannizzaro, C.; Daheron, L.; Messmer, B.; Vunjak-Novakovic, G.; Kaplan, D. L. Biomaterials 2007,28, 5271.

6 Li, M.; Wu, Z.; Lu, S.; Sun, D.; Liao, Z.; Zhang, J. CN1628864A, 2005 [Chem. Abstr. 2006, 146,79446].

7 Fan, H.; Liu, H.; Toh, S. L.; Goh, J. C. H. Biomaterials2008, 29, 1017.

8 Li, M.; Tao, W.; Lu, S.; Kuga, S. Int. J. Biol. Macromol.2003, 32, 159.

9 Park, K. E.; Jung, S. Y.; Lee, S. J.; Min, B. M.; Park, W. H. Int. J. Biol. Macromol. 2006, 38, 165.

10 Li, M.; Wu, Z.; Zhang, C.; Lu, S.; Yan, H.; Huang, D.; Ye, H. J. Appl. Polym. Sci. 2001, 79, 2192.

11 Kim, U. J.; Park, J.; Kim, H. J.; Wada, M.; Kaplan, D. L. Biomaterials 2005, 26, 2775.

12 Lu, S.; Wang, X.; Lu, Q.; Zhang, X.; Kluge, J. A.; Uppal, N.; Omenetto, F.; Kaplan, D. L. Biomacromolecules 2010,11, 143.

13 Lu, S.; Wang, X.; Lu, Q.; Zhang, X.; Kluge, J. A.; Uppal, N.; Omenetto, F.; Kaplan, D. L. Biomacromolecules 2010,11, 143.

14 Tamada, Y. Biomacromolecules 2005, 6, 3100.

15 Tsukada, M.; Freddi, G.; Kasai, N.; Monti, P. J. Polym. Sci. B: Polym. Phys. 1998, 36, 2717.

16 Hais, P. I.; Severcan, F. J. Mol. Catal. B: Enzym. 1999, 7,207.

17 Byler, D. M.; Susi, H. Biopolymers 1986, 25, 469.

18 Hae, Y. K.; Park, Y. H. Biomaterils 1999, 73, 2887.

19 Cai, S.; Singh, B. R. Biophys. Chem. 1999, 80, 7.

20 Xie, M. X.; Liu, Y. Chem. J. Chin. Univ. 2003, 24, 226 (in Chinese). (谢孟峡, 刘媛, 高等学校化学学报, 2003, 24, 226.)

21 Chen, X.; Zhou, L.; Shao, Z. Z.; Knight, D. P.; Vollrath, F. Acta Chim. Sinica 2003, 61, 625 (in Chinese). (陈新, 周丽, 邵正中, Knight, D. P., Vollrath, F. 化学学报,2003, 61, 625.)

22 Chen, X.; Shao, Z.; Knight, D. P.; Vollrath, F. Proteins: Struct., Funct., Bioinf. 2007, 68, 223.

23 Marsh, R. E.; Corey, R. B.; Pauling, L. Biochem. Biophys. Acta 1955, 16, 61.

24 Konishi, T.; Kurokawa, M. Sen'i Gakkaishi 1968, 24, 550.

25 Li, M. Z.; Ogisob, M.; Minoura, N. Biomaterials 2003, 24,357.

26 Kweon, H. Y.; Um, I. C.; Park, Y. H. Polymer 2001, 42,6651.

27 Gil, E. S.; Frankowski, D. J.; Bowman, M. K.; Gozen, A. O.; Hudson, S. M.; Spontak, R. J. Biomacromolecules 2006,7, 728.

28 Tamada, Y. Biomacromolecules 2005, 6, 3100.

29 Kima, U. J.; Park, J. H.; Kim, H. J.; Wada, M.; Kaplan, D. L. Biomaterials 2005, 26, 2775.

30 Zhang, J. W.; Gu, J. K. Dynamics of Controlled/Sustained Release Dosage Form, Science Press, Beijing, 2009, pp.27～50 (in Chinese). (张继稳, 顾景凯, 缓控释制剂药物动力学, 科学出版社, 北京, 2009, pp. 27～50.)

31 Horan, R. L.; Antle, K.; Collette, A. L.; Wang, Y. Z.; Huang, J.; Moreau, J. E.; Volloch, V.; Kaplan, D. L.; Altman, G. H. Biomaterials 2005, 26, 3385.

32 Rigter, P. L.; Peppas, N. A. J. Controlled Release 1987, 5,37.

33 Colombo, P.; Bettini, R.; Santi, P.; Ascentiis, A.; Peppas, N. A. J. Controlled Release 1996, 39, 231.

34 Yoshimizu, H.; Asakura, T. J. Appl. Polym. Sci. 1990, 40,1745.

35 Heslot, H. Biochimie 1998, 80, 19.

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甲醇-水混合溶剂后处理制备丝素蛋白膜及其药物释放研究

Controlled Drug Release from Silk Fibroin Films Treated with Methanol-water Mixtures

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