Electrochemical Sensor for the Determination of Theophylline Based on Molecularly Imprinted Polymer with Ethylene Glycol Maleic Rosinate Acrylate as Cross-linker

doi:10.6023/A1108232

Acta Chimica Sinica ›› 2012, Vol. 70 ›› Issue (9): 1088-1094.DOI: 10.6023/A1108232 Previous Articles Next Articles

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以马来松香丙烯酸乙二醇酯为交联剂的茶碱分子印迹膜电化学传感器的研究

谭学才^a,b, 王琳^b, 李鹏飞^a, 龚琦^b, 刘力^a, 赵丹丹^a, 雷福厚^a, 黄在银^a

a. 广西民族大学化学化工学院广西林产化学与工程重点实验室广西高校化学与生物转化过程重点实验室南宁 530008;
b. 广西大学化学化工学院南宁 530004

投稿日期:2011-08-23 修回日期:2012-04-09 发布日期:2012-04-18
通讯作者: 谭学才 E-mail:xctan@yahoo.cn
基金资助:
国家自然科学基金(Nos. 21065001, 30960306, 21165003)、广西自然科学基金(Nos. 0991084, 0991001z)、广西教育厅科研(Nos. 200812MS074)、广西林产化学品开发与应用重点实验室(No. GXFC08-06)资助项目.

Electrochemical Sensor for the Determination of Theophylline Based on Molecularly Imprinted Polymer with Ethylene Glycol Maleic Rosinate Acrylate as Cross-linker

Tan Xuecai^a,b, Wang Lin^b, Li Pengfei^a, Gong Qi^b, Liu Li^a, Zhao Dandan^a, Lei Fuhou^a, Huang Zaiyin^a

a. School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Chemical and Biological Transforming Process in Universities of Guangxi, Nanning 530008;
b. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004

Received:2011-08-23 Revised:2012-04-09 Published:2012-04-18
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21065001, 30960306, 21165003), Guangxi Natural Science Foundation (Nos. 0991084, 0991001z), Scientific Reserch Fund of Guangxi Education Department (Nos. 200812MS074) and Guangxi Key Laboratory of Chemistry and Engineering of Forest Products (No. GXFC08-06).

A novel electrochemical sensor for the determination of theophylline based on ethylene glycol maleic rosinate acrylate as the cross linking agent and acrylic acid as functional monomer was fabricated by molecularly imprinted technology. A molecularly imprinted polymers (MIPs) membrane was synthesized on the surface of a glassy carbon electrode in vacuum drying oven by free radical polymerization method. The electrochemical behavior of the membrane was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry. Under optimum conditions, it was found that the response of peak currents was linear to the concentration of theophylline in range of 2.00×10^-7～3.45×10^-4 mol/L (linear regression coefficient＝0.9961) with the detection limit of 1.00×10^-7 mol/L. The sensor not only has high selectivity, but also shows good stability and reproducibility. The sensor was applied to the determination of theophylline in theophylline sustained release tablets samples with recovery ranging from 95.6% to 103.8%.

Key words: ethylene glycol maleic rosinate acrylate, theophylline, molecularly imprinted polymer, electrochemical sensor

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Tan Xuecai, Wang Lin, Li Pengfei, Gong Qi, Liu Li, Zhao Dandan, Lei Fuhou, Huang Zaiyin. Electrochemical Sensor for the Determination of Theophylline Based on Molecularly Imprinted Polymer with Ethylene Glycol Maleic Rosinate Acrylate as Cross-linker[J]. Acta Chimica Sinica, 2012, 70(9): 1088-1094.

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1 Zhang, L.-K.; Li, X.-F.; Yang F.-L. Chem. Reag. 2010, 32,

626 (in Chinese). (张立科, 李学峰, 杨风岭, 化学试剂, 2010, 32, 626.)

2 Wang, N.-X.; Yu, T.-D.; Chen, Y.-W. Chin. J. Anal. Chem.1990, 18, 338 (in Chinese). (汪乃兴, 俞棠棣, 谌英武, 分析化学, 1990, 18, 233.)

3 Meng, Z.-R.; Zhan, Y.-F. Electrochemistry 1997, 3, 338 (in Chinese). (孟昭仁, 战永复, 电化学, 1997, 3, 338.)

4 Zen, J. M.; Yu, T. Y.; Shih, Y. Talanta 1999, 50, 635.

5 Xu, Q.-Q.; Du, L.-M.; Wang, J.-P.; Bai, A.-H. J. Anal. Sci.2002, 18, 520 (in Chinese). (许庆琴, 杜黎明, 王静平, 白爱华, 分析科学学报, 2002, 18, 520.)

6 Fan, Y.; Feng, Y. Q.; Da, S. L.; Shi, Z. G. Anal. Chim. Acta2004, 523, 251.

7 Fiona, R.; Yuliya, S. Anal. Chim. Acta 2005, 540, 103.

8 Qian, L. Z.; Hong, Z. L.; Wei, H. W.; Hong, Y. C. J. Chromatogr. A 2005, 1098, 172.

9 Singh, D. K.; Archana, S. Anal. Biochem. 2006, 349, 176.

10 Qiao, H.-Y.; Wang, Z.-H.; Wang, D.; Huang, A.-P.; Chen, T.-W. Chin. J. Anal. Lab. 2009, 28, 5 (in Chinese). (乔海燕, 汪振辉, 王栋, 黄爱平, 陈体伟, 分析试验室,2009, 28, 5.)

11 Vlatakis, G.; Andersson, L. I.; Müller, R.; Mosbach, K. Nature1993, 361, 645.

12 Shi, H. Q.; Tsaiw, W. B.; Garrison, M. D.; Ferrari S.; Ratner, B. D. Nature 1999, 398, 593.

13 Ma, X.-X.; He, X.-W.; Zhang, M.; Li, W.-Y.; Zhang, Y.-K. Acta Chim. Sinica 2006, 64, 2369 (in Chinese). (马向霞, 何锡文, 张茉, 李文友, 张玉奎, 化学学报,2006, 64, 2369.)

14 Lei, F.-H.; Zuo, Z.-Y.; Liu, Z.-G.; Bai, L.-J.; Lan, H.-Y. CNP10051902.8, 2007 [National Standards of the People's Republic of China, 2007].

15 Zhou, L.; Ye, G.-R.; Yuan, R.; Chai, Y.-Q.; Chen, S.-M. Sci. China Ser. B-Chem. 2007, 37, 48 (in Chinese). (周路, 叶光荣, 袁若, 柴雅琴, 陈素明, 中国科学B 辑: 化学, 2007, 37, 48.)

16 Hou, N.-B.; Liu, Y.-L.; Wang, G.-S.; Zhu, X.-F.; Ding, Z.-T.; Cao, Q.-E. Acta Chim. Sinica 2006, 64, 1705 (in Chinese). (侯能邦, 刘院林, 汪国松, 朱秀芳, 丁中涛, 曹秋娥, 化学学报, 2006, 64, 1705.)

17 Zhuo, D.; Chen, Z.; Wang, X.-L.; Ruan, Y.-B.; Zhao, X.-M.; Ran, R. Acta Polym. Sinica 2010, (5), 561 (in Chinese). (卓丁, 陈智, 王晓龙, 阮英波, 赵雪梅, 冉蓉, 高分子学报, 2010, (5), 561.)

18 Lei, F.-H.; Zhao, K.; Li, X.-Y.; Lu, J.-F.; Guan, Y.-T. Fine Chem. 2010, 27, 11 (in Chinese). (雷福厚, 赵慷, 李小燕, 卢建芳, 关瑜婷, 精细化工,2010, 27, 11.)

19 Kharitonov, A. B.; Alfonta, L.; Katz, E.; Willner, I. J. Electroanal. Chem. 2000, 487, 133.

20 Khorrami, A. R.; Rashidpur, A. Biosens. Bioelecron. 2009,25, 647.

21 Lai, E. P.; Fafara, A.; VanderNoot, V. A. Can. J. Chem.1998, 76, 265.

22 Lu, C.-M.; Wang, R.-Y. J. Henan Univ. Technol. (Nat. Sci. Ed.) 2006, 26, 7 (in Chinese). (路纯明, 王仁育, 河南工业大学学报(自然科学版),2006, 26, 7.)

23 Riahi, S.; Mousavi, M. F.; Bathaie, S. Z.; Shamsipur, M. Anal. Chim. Acta 2005, 548, 192.

24 Wang , Z. H.; Kang, J. W.; Liu, X. Y.; Ma, Y. J. Int. J. Polym. Anal. Charact. 2007, 12, 131

25 Kan, X. W.; Liu, T. T.; Zhou, H.; Li, C.; Fang, B. Microchim. Acta 2010, 171, 423.

26 Lisa, M. K.; Evangelyn, C. A. Sensors 2007, 7, 1630.

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以马来松香丙烯酸乙二醇酯为交联剂的茶碱分子印迹膜电化学传感器的研究

Electrochemical Sensor for the Determination of Theophylline Based on Molecularly Imprinted Polymer with Ethylene Glycol Maleic Rosinate Acrylate as Cross-linker

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